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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.2
- 수록면
- 116 - 121 (6page)
- DOI
- https://doi.org/10.5483/BMBRep.2023-0239
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초록· 키워드
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We investigated the therapeutic potential of bone marrow-de rived mesenchymal stem cell-conditioned medium (BMSC-CM)on immortalized renal proximal tubule epithelial cells (RPTEC/TERT1) in a fibrotic environment. To replicate the increasedstiffness characteristic of kidneys in chronic kidney disease, weutilized polyacrylamide gel platforms. A stiff matrix was shownto increase α-smooth muscle actin (α-SMA) levels, indicatingfibrogenic activation in RPTEC/TERT1 cells. Interestingly, treat ment with BMSC-CM resulted in significant reductions in thelevels of fibrotic markers (α-SMA and vimentin) and increases inthe levels of the epithelial marker E-cadherin and aquaporin 7,particularly under stiff conditions. Furthermore, BMSC-CM modi fied microRNA (miRNA) expression and reduced oxidative stresslevels in these cells. Our findings suggest that BMSC-CM canmodulate cellular morphology, miRNA expression, and oxidativestress in RPTEC/TERT1 cells, highlighting its therapeutic potentialin fibrotic kidney disease.
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