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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 594 - 599 (6page)
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Lin28a has diverse functions including regulation of cancer, reprogramming and regeneration, but whether it promotes injury or is a protective reaction to renal injury is unknown. We studied how Lin28a acts in unilateral ureteral obstruction (UUO)-induced renal fibrosis following unilateral ureteral obstruction, in a mouse model. We further defined the role of Lin28a in transforming growth factor (TGF)-signaling pathways in renal fibrosis through in vitro study using human tubular epithelium-like HK-2 cells. In the mouse unilateral ureteral obstruction model, obstruction markedly decreased the expression of Lin28a, increased the expression of renal fibrotic markers such as type I collagen, α-SMA, vimentin and fibronectin. In TGF-β-stimulated HK-2 cells, the expression of Lin28a was reduced and the expression of renal fibrotic markers such as type I collagen, α-SMA, vimentin and fibronectin was increased. Adenovirus-mediated overexpression of Lin28a inhibited the expression of TGF-β-stimulated type I collagen, α-SMA, vimentin and fibronectin. Lin28a inhibited TGF-β-stimulated SMAD3 activity, via inhibition of SMAD3 phosphorylation, but not the MAPK pathway ERK, JNK or p38. Lin28a attenuates renal fibrosis in obstructive nephropathy, making its mechanism a possible therapeutic target for chronic kidney disease.
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참고문헌 (44)
참고문헌 신청
Norman JT / 1999 / Hypoxianduced changes in extracellular matrix metabolism in renal cells / Exp Nephrol 7:463~493
Zeisberg M / 2004 / Experimental strategies to reverse chronic renal disease / Blood Purif 22:440~445
Harris RC / 2006 / Toward a unified theory of renal progression / Annu Rev Med 57:365~380
De Vecchi AF / 1999 / Healthcare systems and end-stage renal disease (ESRD) therapies—an international review: costs and reimbursement/funding of ESRD therapies / Nephrol Dial Transplant 14(Suppl 6):31~41
Remuzzi G / 2006 / Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes / J Clin Invest 116:288~296
Zeisberg M / 2004 / Experimental strategies to reverse chronic renal disease / Blood Purif 22:440~445
Harris RC / 2006 / Toward a unified theory of renal progression / Annu Rev Med 57:365~380
De Vecchi AF / 1999 / Healthcare systems and end-stage renal disease (ESRD) therapies—an international review: costs and reimbursement/funding of ESRD therapies / Nephrol Dial Transplant 14(Suppl 6):31~41
Remuzzi G / 2006 / Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes / J Clin Invest 116:288~296
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