지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.6
- 수록면
- 107 - 121 (15page)
이용수
초록· 키워드
오류제보하기
Clostridioides difficile is a spore-forming enteric pathogen that causes life-threatening diarrhea and colitis. Notably, C. difficile infection (CDI) is a major healthcare-associated infection with increasing incidence and morbidity rates. Antibiotic-induced microbial disruption has been linked to susceptibility to CDI transmission and relapse. Therefore, alternative therapeutic approaches that effectively prevent C. difficile growth and spore germination are urgently needed. Bacteriophage-derived endolysins and their derivatives have recently shown potential as novel antibacterial agents. Hence, this study aimed to investigate the efficacy of a novel truncated cysteine-histidine-dependent amidohydrolase/peptidase (CHAP) modular endolysin, CHAP<SUP>SAP26</SUP>-161, in combating CDI. In vitro studies demonstrated its potent bactericidal activity against several clinically relevant C. difficile strains, including toxin A- and toxin B-producing and nontoxigenic strains. CHAP<SUP>SAP26</SUP>-161 exhibited rapid and specific killing activity, thereby significantly reducing C. difficile colony-forming units. Furthermore, in a murine CDI model, CHAP<SUP>SAP26</SUP>-161 treatment remarkably reduced C. difficile burden and clinical symptoms, such as diarrhea and weight loss. In histopathological analysis, colonic inflammation and tissue damage decreased in CHAPSAP26-161-treated mice compared with that in the control group. Moreover, no cytotoxic effects were observed on the A549 cell line, indicating that CHAP<SUP>SAP26</SUP>-161 is safe as a therapeutic agent. These findings highlight that CHAP<SUP>SAP26</SUP>-161 is a promising treatment option for CDI. Importantly, preclinical and clinical studies are warranted to fully evaluate the therapeutic potential of CHAPSAP26-161 and its possible implementation in clinical practice.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Exploring Endolysins as a Therapeutic Agent against Clostridioides difficile Infection
한국미생물학회 학술대회논문집
2022 .10
-
Genomic Characterization of Nine Clostridioides difficile Strains Isolated from Korean Patients with Clostridioides difficile Infection
한국미생물학회 학술대회논문집
2021 .08
-
Identification of a Novel Human Gut Microbiota Inhibiting Growth of Clostridioides difficile through Membrane Disruptive Activity and Restoring Gut Microbial Community in C. difficile Infection
한국미생물학회 학술대회논문집
2022 .10
-
In vitro and in vivo anti- Clostridioides difficile effect of a probiotic Bacillus amyloliquefaciens strain
Journal of Microbiology and Biotechnology
2022 .01
-
Identification and Functional Description of Clostridioides difficile Hydrogen Peroxide Sensor (PerR)
한국미생물학회 학술대회논문집
2021 .08
-
Efficacy Assessment of the Co-Administration of Vancomycin and Metronidazole in Clostridioides difficile -Infected Mice Based on Changes in Intestinal Ecology
Journal of Microbiology and Biotechnology
2024 .04
-
Diagnosis of Clostridium difficile infection in patients with hospital-acquired diarrhea
미생물학회지
2018 .09
-
Trends in Bacteria Causing Diarrheal Infection from 2010 to 2018 in Cheonan, Korea: Aeromonas spp., Campylobacter spp., and Clostridioides spp.
한국미생물·생명공학회지
2019 .01
-
A Novel Truncated CHAP Modular Endolysin, CHAP SAP26 -161, That Lyses Staphylococcus aureus , Acinetobacter baumannii , and Clostridioides difficile , and Exhibits Therapeutic Effects in a Mouse Model of A. baumannii Infection
Journal of Microbiology and Biotechnology
2024 .08
-
A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift
Journal of Microbiology and Biotechnology
2016 .01
-
Research Progress on Strategies for Improving the Enzyme Properties of Bacteriophage Endolysins
Journal of Microbiology and Biotechnology
2024 .06
-
인공관절 수술 후 감염과 비 감염에 따른 C-반응성단백과 적혈구침강속도의 변화 추이
대한임상검사과학회지
2016 .01
-
제주특별자치도 종합병원의 감염관리 현황
대한임상검사과학회지
2016 .01
-
Clostridium difficile Toxin A Induces Reactive Oxygen Species Production and p38 MAPK Activation to Exert Cellular Toxicity in Neuronal Cells
Journal of Microbiology and Biotechnology
2017 .06
-
Increase in dietary protein content exacerbates colonic inflammation and tumorigenesis in azoxymethane-induced mouse colon carcinogenesis
Nutrition Research and Practice
2017 .08
-
Increase in dietary protein content exacerbates colonic inflammation and tumorigenesis in azoxymethane-induced mouse colon carcinogenesis
Nutrition Research and Practice
2017 .08
-
감염관리를 위한 항생제 사용량 데이터마트의 구축
대한임상검사과학회지
2016 .01
-
요양보호사의 감염관리 수행도 관련요인
경북간호과학지
2021 .01
-
Discovery of New Antibacterial Molecules to Combat Bacterial Infections
한국미생물학회 학술대회논문집
2015 .04
-
Inhibitory Effect of Bacteroides ovatus on Clostridium difficile Growth Mediated by Bile Salts Hydrolase
한국미생물학회 학술대회논문집
2019 .04
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-151-24-02-090106240