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논문 기본 정보

자료유형
학술저널
저자정보
Wang Yulu (Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, P.R. ChinaDongguan Key Laboratory of Public Health Laboratory Science, School of Public Health, Guangdong M) Wang Xue (Dongguan Key Laboratory of Public Health Laboratory Science, School of Public Health, Guangdong Medical University, Dongguan 523808, P.R. China) Liu Xin (Dongguan Key Laboratory of Public Health Laboratory Science, School of Public Health, Guangdong Medical University, Dongguan 523808, P.R. China) Lin Bokun (Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, P.R. ChinaDongguan Key Laboratory of Public Health Laboratory Science, School of Public Health, Guangdong M)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.6
발행연도
2024.6
수록면
1,189 - 1,196 (8page)
DOI
10.4014/jmb.2312.12050

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Bacterial resistance to commonly used antibiotics is one of the major challenges to be solved today. Bacteriophage endolysins (Lysins) have become a hot research topic as a new class of antibacterial agents. They have promising applications in bacterial infection prevention and control in multiple fields, such as livestock and poultry farming, food safety, clinical medicine and pathogen detection. However, many phage endolysins display low bactericidal activities, short half-life and narrow lytic spectrums. Therefore, some methods have been used to improve the enzyme properties (bactericidal activity, lysis spectrum, stability and targeting the substrate, etc) of bacteriophage endolysins, including deletion or addition of domains, DNA mutagenesis, chimerization of domains, fusion to the membrane-penetrating peptides, fusion with domains targeting outer membrane transport systems, encapsulation, the usage of outer membrane permeabilizers. In this review, research progress on the strategies for improving their enzyme properties are systematically presented, with a view to provide references for the development of lysins with excellent performances.

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