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논문 기본 정보

자료유형
학술저널
저자정보
Manabu Seino (Yamagata University Faculty of Medicine) Satoru Nagase (Yamagata University Faculty of Medicine) Tsuyoshi Ohta (Yamagata University Faculty of Medicine) Wataru Yamagami (Keio University School of Medicine) Yasuhiko Ebina (Hokkaido University Japan) Yoichi Kobayashi (Kyorin University School of Medicine) Tsutomu Tabata (Tokyo Women) Masanori Kaneuchi (Otaru General Hospital) Takayuki Enomoto (Niigata University School of Medicine Niigata Japan) Mikio Mikami (Tokai University School of Medicine)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.34 No.1
발행연도
2023.1
수록면
1 - 11 (11page)
DOI
https://doi.org/10.3802/jgo.2023.34.e4

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초록· 키워드

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Objective: The aim of this study was to review the clinicopathological characteristics of smallcell neuroendocrine cer vical cancer (SCNEC) and to identif y the optimal treatment. Methods: The Japanese Society of Gynecologic Oncology conducted a retrospective cohortstudy of SCNECs enrolled in the Gynecological Tumor Registr y of the Japan Society ofObstetrics and Gynecology between 2004 and 2015. All cases were modified and unified byInternational Federation of Gynecology and Obstetrics 2008 (Union for International CancerControl 7th edition). Results: There were 822 registered patients diagnosed with SCNEC from 2004 to 2015which comprised 1.1% (822/73,698) of all uterine cer vical cancer cases. Rates of lymph-nodeand distant metastasis were significantly higher in T1b2 (38.9% and 13.7%, respectively)than T1b1 (14.2% and 4.4%, respectively) (p<0.01). In IB2 and T1bN1M0 SCNEC, the 5-yearsur vival rate with surger y followed by chemotherapy was significantly higher than that withsurger y followed by radiation therapy/concurrent chemoradiation therapy (p<0.01). Conclusion: SNCEC tumors >4 cm in size had greater rates of lymph-node and distantmetastasis when compared with tumors ≤4 cm. Adjuvant chemotherapy, rather thanradiotherapy, may improve prognosis after surger y in T1bN1M0 SCNEC.

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