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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.5
- 수록면
- 1 - 10 (10page)
- DOI
- 10.3802/jgo.2023.34.e55
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초록· 키워드
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Background: Cer vical cancer is still present a major public health problem, especially indeveloping countries. In International Federation of Gynaecology and Obstetrics 2018,allowing assessment of retroperitoneal lymph nodes by imaging and/or pathological findingsand, if deemed metastatic, the case is designated as stage IIIC (with r and p notations).
Patients with lymph node metastases have lower overall sur vival (OS), progression freesur vival (PFS), and sur vival after recurrence, especially those who have unresectablemacroscopical positive lymph nodes. Retrospective analysis suggests that there may be abenefit to debulking macroscopic nodes that would be other wise difficult to sterilize withstandard doses of radiation therapy. However, there are no prospective study reporting thatresecting macroscopic nodes before concurrent chemoradiation therapy (CCRT) wouldimprove PFS or OS of cer vical cancer and no guidelines for surgical resection of bulky lymphnodes. The CQGOG0103 study is a prospective, multicenter and randomized controlled trial(RCT) evaluating lymph node dissection on stage IIICr of cer vical cancer.
Methods: Eligible patients are histologically confirmed cer vical squamous cell carcinoma,adenocarcinoma, adeno-squamous cell carcinoma. Stage IIICr (confirmed by computedtomography [CT]/magnetic resonance imaging/positron emission tomography/CT) andthe short diameter of image-positive lymph node ≥15 mm. 452 patients will be equally randomized to receive either CCRT (pelvic external-beam radiotherapy [EBRT]/extended-field EBRT + cisplatin [40 mg/m2] or carboplatin [the area under cur ve=2] ever y week for5 cycles + brachytherapy) or open/minimally invasive pelvic and para-aortic lymph nodedissection followed by CCRT. Randomization is stratified by status of para-aortic lymphnode. The primar y endpoint is PFS. Secondar y endpoints are OS and surgical complications.
A total of 452 patients will be enrolled from multiple hospitals in China within 4 years andfollowed up for 5 years.
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