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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.1
- 수록면
- 1 - 15 (15page)
- DOI
- https://doi.org/10.3802/jgo.2023.34.e11
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초록· 키워드
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Background: Endometrial carcinoma (EC) is one of the most common malignant tumorsof the female reproductive tract, involving multiple molecular alterations. Circular RNA(circRNA) dysregulation is frequently obser ved in EC tissues, suggesting the involvement ofcircRNA in EC development. We aimed to investigate the role of circ_0075960 in EC.
Methods: Real-time quantitative polymerase chain reaction (RT-qPCR) and western blotassays were applied for expression analysis. CCK-8, EdU, colony formation, flow cytometr yand wound healing assays were employed for functional analysis. The predicted bindingrelationship between miR-202-5p and circ_0075960 or CTNND1 was validated by dual-luciferase reporter experiment. In vivo animal models were constructed in nude mice to verif ythe role of circ_0075960 in tumor growth.
Results: Circ_0075960 and CTNND1 were upregulated, while miR-202-5p wasdownregulated in EC. Knockdown of circ_0075960 induced EC cell apoptosis, suppressedcell proliferation and migration, and repressed tumor growth in animal models. MiR-202-5p was targeted by circ_0075960 and it directly bound to CTNND1 3’UTR. The inhibitionof circ_0075960 knockdown or miR-202-5p enrichment on EC cell proliferation andmigration was reversed by miR-202-5p depletion or CTNND1 overexpression, respectively.
Circ_0075960 targeted miR-202-5p to positively regulate CTNND1 expression. Moreover,circ_0075960 knockdown weakened the activity of Wnt/β-catenin signaling via targeting themiR-202-5p/CTNND1 axis.
Conclusion: Circ_0075960 targets the miR-202-5p/CTNND1 axis to modulate Wnt/β-cateninsignaling activity, thus contributing to the malignant development of EC.
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