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논문 기본 정보

자료유형
학술저널
저자정보
Sheng-Min Wang (Department of Psychiatry Catholic Center for Brain Health Yeouido St. Mary’s Hospital College of Me) Sung-Soo Park (The Catholic University of Korea) See Hyun Park (The Catholic University of Korea) Nak-Young Kim (The Catholic University of Korea) Dong Woo Kang (Department of Psychiatry Seoul St. Mary’s Hospit) Hae-Ran Na (The Catholic University of Korea) Young-Yi Bae (The Catholic University of Korea) Jong Wook Lee (The Catholic University of Korea) Seunghoon Han (The Catholic University of Korea) Hyun Kook Lim (The Catholic University of Korea)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제2호
발행연도
2021.1
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294 - 302 (9page)

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Objective: No previous study examined impact of dementia in the outcome of allogeneic hematopoietic stem cell transplantation (HSCT). We aimed to investigate overall survival (OS) of patients with dementia after receiving HSCT. Methods: Among 8,230 patients who underwent HSCT between 2002 and 2018, 5,533 patients younger than 50 years were first excluded. Remaining patients were divided into those who were and were not diagnosed with dementia before HSCT (dementia group: n = 31; no dementia: n = 2,666). Thereafter, among 2,666 participants without dementia, 93 patients were selected via propensity-matched score as non-dementia group. Patients were followed from the day they received HSCT to the occurrence of death or the last follow-up day (December 31, 2018), whichever came first. Results: With median follow-up of 621 days for dementia group and 654 days for non-dementia group, 2 year-OS of dementia group was lower than that of non-dementia group (53.3% [95% confidence interval, 95% CI, 59.0?80.2%] vs. 68.8% [95% CI, 38.0?68.2%], p = 0.076). In multivariate analysis, dementia had significant impacts on OS (hazard risk = 2.539, 95% CI, 1.166?4.771, p = 0.017). Conclusion: Our results indicated that patients diagnosed with dementia before HSCT have 2.539 times higher risk of mortality after transplantation than those not having dementia. With number of elderly needing HSCT is increasing, further work to establish treatment guidelines for the management of HSCT in people with dementia is needed.

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