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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 365 - 372 (8page)
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초록· 키워드
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Purpose: The development of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) deteriorates patients’ quality of life. This study aimed to analyze the prevalence, clinical features, risk factors and prognosticfactors of BOS.
Materials and Methods: This retrospective study included patients who underwent allogeneic HSCT from January 2002 to December2008 and survived for ≥100 days after transplantation.
Results: Of 860 patients who survived for ≥100 days, 36 (4.2%) met the diagnostic criteria. The duration of BOS development after transplantation was 466.00 (284.00–642.75) [median (interquartile range)] days. The risk factor for the development of BOS was peripheral blood as the stem cell source with a hazard ratio (HR) of 2.550 [95% confidence interval (CI): 1.274–5.104, p=0.008]. In multivariate analysis, pretransplant FEV1/FVC (HR: 0.956, 95% CI: 0.921–0.993, p=0.020) and time from HSCT to diagnosis of BOS (HR: 0.997, 95% CI: 0.994–0.999, p=0.009) were independent prognostic factors associated with mortality.
Conclusion: Peripheral blood as a stem cell source is a risk factor for the development of BOS. A decreased pretransplant FEV1/FVC and shorter duration of time from transplantation to diagnosis of BOS are poor prognostic factors for BOS.
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참고문헌 (29)
참고문헌 신청
Williams KM / 2009 / Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation / JAMA 302:306~314
Chien JW / 2010 / Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease / Biol Blood Marrow Transplant 16(1Suppl):S106~S114
Chien JW / 2011 / Preventing and managing bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation / Expert Rev Respir Med 5:127~135
Pandya CM / 2010 / Bronchiolitis obliterans following hematopoietic stem cell transplantation: a clinical update / Clin Transplant 24:291~306
Santo Tomas LH / 2005 / Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia / Chest 128:153~161
Chien JW / 2010 / Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease / Biol Blood Marrow Transplant 16(1Suppl):S106~S114
Chien JW / 2011 / Preventing and managing bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation / Expert Rev Respir Med 5:127~135
Pandya CM / 2010 / Bronchiolitis obliterans following hematopoietic stem cell transplantation: a clinical update / Clin Transplant 24:291~306
Santo Tomas LH / 2005 / Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia / Chest 128:153~161
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