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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 49 - 55 (7page)
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Aging is characterized by a gradual decline in biological functions,leading to the increased probability of diseases and deathsin organisms. Previous studies have identified biological factorsthat modulate aging and lifespan, including non-coding RNAs(ncRNAs). Here, we review the relationship between aging andtRNA-derived small RNAs (tsRNAs), ncRNAs that are generatedfrom the cleavage of tRNAs. We describe age-dependent changesin tsRNA levels and their functions in age-related diseases, suchas cancer and neurodegenerative diseases. We also discuss theassociation of tsRNAs with aging-regulating processes, includingmitochondrial respiration and reduced mRNA translation. Wecover recent findings regarding the potential roles of tsRNAs incellular senescence, a major cause of organismal aging. Overall,our review will provide useful information for understanding theroles of tsRNAs in aging and age-associated diseases.
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