Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity

Shu Zhang; Mei-qing Qiu; Hui-jun Wang; Ya-fei Ju; Zhen Liu; Tao Wang; Shi-feng Kan; Zhen Yang; Ya-yun Cui; You-qiang Ke; Hong-min He; Li Sun

doi:10.5230/jgc.2023.23.e19

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자료유형: 학술저널

저자정보: Shu Zhang (Department of Gastroenterology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences China) Mei-qing Qiu (Shandong University Cancer Center Jinan China) Hui-jun Wang (Department of Gastroenterology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences China) Ya-fei Ju (Department of Gastroenterology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences China) Zhen Liu (Department of Gastroenterology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences China) Tao Wang (Department of Oncology Zaozhuang Cancer Hospital Zaozhuang China) Shi-feng Kan (Department of Oncology Zaozhuang Municipal Hospital Zaozhuang China) Zhen Yang (Department of Oncology Zaozhuang Municipal Hospital Zaozhuang China) Ya-yun Cui (Department of Gastroenterology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences China) You-qiang Ke (Molecular Pathology Laboratory Department of Molecular and Clinical Cancer Medicine Liverpool University Liverpool United Kingdom) Hong-min He (Department of Oncology Zaozhuang Municipal Hospital Zaozhuang China) Li Sun (Department of Gastroenterology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences China)

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제23권 제2호

발행연도: 2023.4

수록면: 340 - 354 (15page)

DOI: 10.5230/jgc.2023.23.e19

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Purpose: Gastric cancer (GC) is the second most lethal cancer globally and is associated with poor prognosis. Fatty acid-binding proteins (FABPs) can regulate biological properties of carcinoma cells. FABP5 is overexpressed in many types of cancers; however, the role and mechanisms of action of FABP5 in GC remain unclear. In this study, we aimed to evaluate the clinical and biological functions of FABP5 in GC. Materials and Methods: We assessed FABP5 expression using immunohistochemical analysis in 79 patients with GC and evaluated its biological functions following in vitro and in vivo ectopic expression. FABP5 targets relevant to GC progression were determined using RNA sequencing (RNA-seq). Results: Elevated FABP5 expression was closely associated with poor outcomes, and ectopic expression of FABP5 promoted proliferation, invasion, migration, and carcinogenicity of GC cells, thus suggesting its potential tumor-promoting role in GC. Additionally, RNA-seq analysis indicated that FABP5 activates immune-related pathways, including cytokine-cytokine receptor interaction pathways, interleukin-17 signaling, and tumor necrosis factor signaling, suggesting an important rationale for the possible development of therapies that combine FABP5-targeted drugs with immunotherapeutics. Conclusions: These findings highlight the biological mechanisms and clinical implications of FABP5 in GC and suggest its potential as an adverse prognostic factor and/or therapeutic target.

#Fatty acid binding protein 5 #Gastric cancer #Biomarker #Interleukin-17

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Shu Zhang

소속기관 Department of Gastroenterology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences China