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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 198 - 198 (1page)
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Background/Aims
The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Recent studies have shown that FABP5 proteins are upregulated in several cancers. The purpose of this study is to determine how FABP5 protein affect the proliferation and metastasis of colorectal cancer (CRC) cell.
Methods
Statistical analyses were performed using NCBI Gene Expression Omnibus (GEO) dataset (GSE41258, GSE39582). The human CRC cell line HCT116-cas 9 cell was culture in RPMI1640 supplemented with 10% fetal bovine serum (FBS) and 50 μg/mL penicillin/streptomycin and maintained at 37 °C in an atmosphere of 5% CO2. We used single-molecular guide (sgRNA) to knockout FABP5 expression. Western blot was used to investigate the level of FABP5 in CRC cells. Additionally, to investigate cell proliferation and metastasis, cell proliferation assay, colony formation assay, wound healing assay and invasion assay were performed. ... 전체 초록 보기
The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Recent studies have shown that FABP5 proteins are upregulated in several cancers. The purpose of this study is to determine how FABP5 protein affect the proliferation and metastasis of colorectal cancer (CRC) cell.
Methods
Statistical analyses were performed using NCBI Gene Expression Omnibus (GEO) dataset (GSE41258, GSE39582). The human CRC cell line HCT116-cas 9 cell was culture in RPMI1640 supplemented with 10% fetal bovine serum (FBS) and 50 μg/mL penicillin/streptomycin and maintained at 37 °C in an atmosphere of 5% CO2. We used single-molecular guide (sgRNA) to knockout FABP5 expression. Western blot was used to investigate the level of FABP5 in CRC cells. Additionally, to investigate cell proliferation and metastasis, cell proliferation assay, colony formation assay, wound healing assay and invasion assay were performed. ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-514-001919692