지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 118 - 123 (6page)
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초록· 키워드
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Background/Aims: The safety of the human body is maintained by effective monitoring of the mucosal surface integrity andprotection against potentially harmful compounds. This function of the gut called intestinal barrier function can be affected bycholestasis and the absence of bile in the intestinal lumen. We aimed to determine whether the gut barrier integrity is impairedin infants with cholestasis by evaluation of the intestinal fatty acid binding proteins (I-FABP) and ileal bile acid binding protein(I-BABP) as markers of intestinal epithelial cell damage and plasma D-lactate level as a marker of gut wall permeability. Methods:This case-control study included 53 infants with cholestasis and 29 controls. Serum levels of I-FABP, I-BABP, and D-lactatewere measured in all subjects. Results: Both groups of patients with neonatal hepatitis and biliary atresia showed significantlyhigher levels of I-FABP and I-BABP than the controls. There were no differences in the serum D-lactate level between the casesand controls. There was no difference between the two groups of patients (I and II) regarding any of the parameters studied. No significant correlations between serum levels of I-FABP, I-BABP, or D-lactate and total or direct bilirubin levels were foundin the cholestatic infants. Conclusions: The intestinal epithelial barrier integrity is breached nearly in all parts of the intestinein infants with cholestasis. Further research is recommended to determine the impact of this finding on the management ofthese infants. The relationship between physical intestinal barrier damage and its functional failure remains subject for furtherresearch.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Moyer V / 2004 / Guideline for the evaluation of cholestatic jaundice in infants: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition / J Pediatr Gastroenterol Nutr 39:115~128
Alaish SM / 2013 / Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host / Gut Microbes 4:292~305
Assimakopoulos SF / 2007 / Intestinal barrier dysfunction in obstructive jaundice: current concepts in pathophysiology and potential therapies / Ann Gastroenterol 20:116~123
Assimakopoulos SF / 2004 / Evidence for intestinal oxidative stress in obstructive jaundice-induced gut barrier dysfunction in rats / Acta Physiol Scand 180:177~185
Brown WR / 1989 / The liver and IgA: immunological, cell biological and clinical implications / Hepatology 9:763~784
Alaish SM / 2013 / Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host / Gut Microbes 4:292~305
Assimakopoulos SF / 2007 / Intestinal barrier dysfunction in obstructive jaundice: current concepts in pathophysiology and potential therapies / Ann Gastroenterol 20:116~123
Assimakopoulos SF / 2004 / Evidence for intestinal oxidative stress in obstructive jaundice-induced gut barrier dysfunction in rats / Acta Physiol Scand 180:177~185
Brown WR / 1989 / The liver and IgA: immunological, cell biological and clinical implications / Hepatology 9:763~784
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