Combinatorial Effect of Mesenchymal Stem Cells and Extracellular Vesicles in a Hydrogel on Cartilage Regeneration

Cho Woong Jin; Ahn Jinsung; Lee Minju; Choi Hyejong; Park Sunghyun; Cha Kyung-Yup; Lee SunJun; Arai Yoshie; Lee Soo-Hong

doi:10.1007/s13770-022-00509-6

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자료유형: 학술저널

저자정보: Cho Woong Jin (Department of Medical Biotechnology Dongguk University) Ahn Jinsung (Department of Medical Biotechnology Dongguk University) Lee Minju (Department of Medical Biotechnology Dongguk University) Choi Hyejong (Department of Medical Biotechnology Dongguk University) Park Sunghyun (Department of Medical Biotechnology Dongguk University) Cha Kyung-Yup (Department of Medical Biotechnology Dongguk University) Lee SunJun (Department of Medical Biotechnology Dongguk University) Arai Yoshie (Department of Medical Biotechnology Dongguk University) Lee Soo-Hong (Department of Medical Biotechnology Dongguk University)

저널정보: 한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제20권 제1호

발행연도: 2023.2

수록면: 143 - 154 (12page)

DOI: 10.1007/s13770-022-00509-6

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Background: Mesenchymal stem cells (MSCs) are used for tissue regeneration due to their wide differentiation capacity and anti-inflammatory effects. Extracellular vesicles (EVs) derived from MSCs are also known for their regenerative effects as they contain nucleic acids, proteins, lipids, and cytokines similar to those of parental cells. There are several studies on the use of MSCs or EVs for tissue regeneration. However, the combinatorial effect of human MSCs (hMSCs) and EVs is not clear. In this study, we investigated the combinatorial effect of hMSCs and EVs on cartilage regeneration via co-encapsulation in a hyaluronic-acid (HA)-based hydrogel. Methods: A methacrylic-acid-based HA hydrogel was prepared to encapsulate hMSCs and EVs in hydrogels. Through in vitro and in vivo analyses, we investigated the chondrogenic potential of the HA hydrogel-encapsulated with hMSCs and EVs. Results: Co-encapsulation of hMSCs with EVs in the HA hydrogel increased the chondrogenic differentiation of hMSCs and regeneration of damaged cartilage tissue compared with that of the HA hydrogel loaded with hMSCs only. Conclusion: Co-encapsulation of hMSCs and EVs in the HA hydrogel effectively enhances cartilage tissue regeneration due to the combinatorial therapeutic effect of hMSCs and EVs. Thus, in addition to cartilage tissue regeneration for the treatment of osteoarthritis, this approach would be a useful strategy to improve other types of tissue regeneration.

#Extracellular vesicles Mesenchymal stem cells Hydrogel Osteoarthritis Chondrogenic differentiation

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