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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 9 (9page)
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Although chronic eosinophilic inflammation is a common feature in patients with asthma, some patients have neutrophildominant inflammation, which is known to be associated with severe asthma.Human mesenchymal stem cells (hMSCs) have shown promise in treating various refractory immunological diseases. Thus, hMSCs may represent an alternative therapeutic option for asthma patients with neutrophil-dominant inflammation, in whom current treatments are ineffective. BALB/c mice exposed to ovalbumin and polyinosinic:polycytidylic acid (Poly I:C) to induce neutrophilic airway inflammation were systemically treated with hMSCs to examine whether the hMSCs can modulate neutrophilic airway inflammation. In addition, cytokine production was evaluated in co-cultures of hMSCs with either anti-CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) obtained from asthmatic patients or cells of the human bronchial epithelial cell line BEAS-2B to assess the response to hMSC treatment. The total number of immune cells in bronchoalveolar lavage fluid (BALF) showed a dramatic decrease in hMSC-treated asthmatic mice, and, in particular, neutrophilic infiltration was significantly attenuated. This phenomenon was accompanied by reduced CXCL15 production in the BALF. BEAS-2B cells co-cultured with hMSCs showed reduced secretion of IL-8. Moreover, decreased secretion of IL-4, IL-13 and IFN-γ was observed when human PBMCs were cultured with hMSCs, whereas IL-10 production was greatly enhanced. Our data imply that hMSCs may have a role in reducing neutrophilic airway inflammation by downregulating neutrophil chemokine production and modulating T-cell responses.
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참고문헌 (26)
참고문헌 신청
Bateman ED / 2008 / Global strategy for asthma management and prevention: GINA executive summary / Eur Respir J 31 : 143 ~ 178
Berair R / 2014 / Asthma therapy and its effect on airway remodelling / Drugs 74 : 1345 ~ 1369
Bernardo ME / 2013 / Mesenchymal stromal cells : sensors and switchers of inflammation / Cell Stem Cell 13 : 392 ~ 402
Birnbaum T / 2007 / Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines / J Neurooncol 83 : 241 ~ 247
Burr SP / 2013 / Mesenchymal stromal cells and regulatory T cells : the Yin and Yang of peripheral tolerance? / Immunol Cell Biol 91 : 12 ~ 18
Berair R / 2014 / Asthma therapy and its effect on airway remodelling / Drugs 74 : 1345 ~ 1369
Bernardo ME / 2013 / Mesenchymal stromal cells : sensors and switchers of inflammation / Cell Stem Cell 13 : 392 ~ 402
Birnbaum T / 2007 / Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines / J Neurooncol 83 : 241 ~ 247
Burr SP / 2013 / Mesenchymal stromal cells and regulatory T cells : the Yin and Yang of peripheral tolerance? / Immunol Cell Biol 91 : 12 ~ 18
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