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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 572 - 577 (6page)
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In most clinical applications, human mesenchymal stem cells (hMSCs) are expanded in large scale before their administration. Prolonged culture in vitro results in cellular senescenceassociated phenotypes, including accumulation of reactive oxygen species (ROS) and decreased cell viabilities. Profiling of stem cell-related genes during in vitro expansion revealed that numerous canonical pathways were significantly changed. To determine the effect of selenocysteine (Sec), a rare amino acid found in several antioxidant enzymes, on the replicative senescence in hMSCs, we treated senescent hMSCs with Sec. Supplementation of Sec in the culture medium in late-passage hMSCs reduced ROS levels and improved the survival of hMSCs. In addition, a subset of key antioxidant genes and Sec-containing selenoproteins showed increased mRNA levels after Sec treatment. Furthermore, ROS metabolism and inflammation pathways were predicted to be downregulated. Taken together, our results suggest that Sec has antioxidant effects on the replicative senescence of hMSCs.
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참고문헌 (27)
참고문헌 신청
Akbaraly NT / 2005 / Selenium and mortality in the elderly: results from the EVA study / Clin Chem 51 : 2117 ~ 2123
Bellinger FP / 2009 / Regulation and function of selenoproteins in human disease / Biochem J 422 : 11 ~ 22
Bianco P / 2013 / The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine / Nat Med 19 : 35 ~ 42
Brighton CT / 1991 / Early histological and ultrastructural changes in medullary fracture callus / J Bone Joint Surg Am 73 : 832 ~ 847
Brighton CT / 1997 / Early histologic and ultrastructural changes in microvessels of periosteal callus / J Orthop Trauma 11 : 244 ~ 253
Bellinger FP / 2009 / Regulation and function of selenoproteins in human disease / Biochem J 422 : 11 ~ 22
Bianco P / 2013 / The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine / Nat Med 19 : 35 ~ 42
Brighton CT / 1991 / Early histological and ultrastructural changes in medullary fracture callus / J Bone Joint Surg Am 73 : 832 ~ 847
Brighton CT / 1997 / Early histologic and ultrastructural changes in microvessels of periosteal callus / J Orthop Trauma 11 : 244 ~ 253
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