표적화 차세대염기서열분석법을 이용한 인수공통 바이러스의 유전체 역학과 예찰

Seonghyeon Lee; Seung-Hwan Bae; Shivani Rajoriya; Sara Puspareni; Won-Keun Kim

doi:10.7853/kjvs.2023.46.1.93

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자료유형: 학술저널

저자정보: Seonghyeon Lee (Hallym University Chuncheon) Seung-Hwan Bae (Hallym University Chuncheon) Shivani Rajoriya (Hallym University Chuncheon) Sara Puspareni (Hallym University Chuncheon) Won-Keun Kim (Hallym University Chuncheon)

저널정보: 한국동물위생학회(구 한국가축위생학회) 한국가축위생학회지 한국가축위생학회지 제46권 제1호

발행연도: 2023.3

수록면: 93 - 106 (14page)

DOI: 10.7853/kjvs.2023.46.1.93

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Emerging and re-emerging zoonotic viruses become critical public health, economic, societal, and cultural burdens. The Coronavirus disease-19 (COVID-19) pandemic reveals needs for effective preparedness and responsiveness against the emergence of variants and the next vi-rus outbreak. The targeted next-generation sequencing (NGS) significantly contributes to the acquisition of viral genome sequences directly from clinical specimens. Using this ad-vanced NGS technology, the genomic epidemiology and surveillance play a critical role in identifying of infectious source and origin, tracking of transmission chains and virus evo-lution, and characterizing the virulence and developing of vaccines during the outbreak. In this review, we highlight the platforms and preparation of targeted NGS for the viral genomics. We also demonstrate the application of this strategy to take advantage of the responsiveness and preven-tion of emerging zoonotic viruses. This article provides broad and deep insights into the prepared-ness and responsiveness for the next zoonotic virus outbreak.

#Genomic epidemiology #Genomic surveillance #Zoonotic viruses #Targeted next-gener-ation sequencing

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