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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Naoya Murakami (National Cancer Center Hospital Tokyo Japan) Miho Watanabe (Graduate School of Medicine Chiba University Chiba Japan) Takashi Uno (Graduate School of Medicine Chiba University Chiba Japan) Shuhei Sekii (Hyogo Cancer Center Hyogo Japan) Kayoko Tsujino (Hyogo Cancer Center Hyogo Japan) Takahiro Kasamatsu (Tokyo Metropolitan Bokutoh Hospital Tokyo Japan) Yumiko Machitori (Tokyo Metropolitan Bokutoh Hospital Tokyo Japan) Tomomi Aoshika (Saitama Medical University International Medical Center Saitama Japan) Shingo Kato (Saitama Medical Center) Hisako Hirowatari (Tokyo Rinkai Hospital Tokyo Japan) Yuko Kaneyasu (National Hospital Organization Fukuyama Medical Center Hiroshima Japan) Tomio Nakagawa (National Hospital Organization Fukuyama Medical Center Hiroshima Japan) Hitoshi Ikushima (Tokushima University Graduate School Tokushima Japan) Ken Ando (Gunma Prefectural Cancer Center Gunma Japan) Masumi Murata (Gunma Prefectural Cancer Center Gunma Japan) Ken Yoshida (Osaka Medical and Pharmaceutical University Osaka Japan) Hiroto Yoshioka (Osaka Medical and Pharmaceutical University Osaka Japan) Kazutoshi Murata (Gunma University Graduate School of Medicine Gunma Japan) Tatsuya Ohno (Gunma University Graduate School of Medicine Gunma Japan) Noriyuki Okonogi (QST Hospital National Institutes for Quantum and Radiological Science and Technology) Anneyuko I. Saito (Juntendo University Faculty of Medicine Tokyo Japan) Mayumi Ichikawa (Yamagata University Faculty of Medicine Yamagata Japan) Takahito Okuda (Toyota Memorial Hospital Aichi Japan) Keisuke Tsuchida (Kanagawa Cancer Center Kanagawa Japan) Hideyuki Sakurai (University of Tsukuba Faculty of Medicine Ibaraki Japan) Ryoichi Yoshimura (Tokyo Medical Dental University Tokyo Japan) Yasuo Yoshioka (Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan) Atsunori Yorozu (National Hospital Organization Tokyo Medical Center Tokyo Japan) Naonobu Kunitake (National Hospital Organization Kyushu Cancer Center Fukuoka Japan) Hiroyuki Okamoto (National Cancer Center Hospital Tokyo Japan) Koji Inaba (National Cancer Center Hospital Tokyo Japan) Tomoyasu Kato (National Cancer Center Hospital Tokyo Japan) Hiroshi Igaki (National Cancer Center Hospital Tokyo Japan) Jun Itami (National Cancer Center Hospital Tokyo Japan)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.34 No.3
발행연도
2023.5
수록면
1 - 16 (16page)
DOI
10.3802/jgo.2023.34.e24

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초록· 키워드

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Objective: The purposes of this trial were to demonstrate the feasibility and effectiveness ofthe hybrid of intracavitar y and interstitial brachytherapy (HBT) for locally advanced cer vicalcancer patients in the phase I/II prospective clinical trial. Methods: Patients with FIGO stage IB2-IVA uterine cer vical cancer pretreatment widthof which was ≥5 cm measured by magnetic resonance imaging were eligible for thisclinical trial. The protocol therapy included 30–30.6 Gy in 15–17 fractions of whole pelvicradiotherapy concurrent with weekly CDDP, followed by 24 Gy in 4 fractions of HBT andpelvic radiotherapy with a central shield up to 50–50.4 Gy in 25–28 fractions. The primar yendpoint of phase II part was 2-year pelvic progression-free sur vival (PPFS) rate higher thanhistorical control of 64%. Results: Between October 2015 and October 2019, 73 patients were enrolled in the initialregistration and 52 patients proceeded to the secondar y registration. With the medianfollow-up period of 37.3 months (range, 13.9–52.9 months), the 2- PPFS was 80.7% (90%confidence inter val [CI]=69.7%–88%). Because the lower range of 90% CI of 2-year PPFS was69.7%, which was higher than the historical control ICBT data of 64%, therefore, the primar yendpoint of this study was met. Conclusion: The effectiveness of HBT were demonstrated by a prospective clinical study. Because the dose goal determined in the protocol was lower than 85 Gy, there is room inimprovement for local control. A higher dose might have been needed for tumors with poorresponses.
#Keywords: Cer vical Cancer #Image Guided Adaptive Brachytherapy #Intracavitar y and Interstitial Brachytherapy #IC/IS

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