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논문 기본 정보

자료유형
학술저널
저자정보
Park So Young (Department of Biotechnology Pukyong National University Busan 48513 Republic of Korea) Choi Jin Won (Department of Biotechnology Pukyong National University Busan 48513 Republic of Korea) Oh Dong Nyoung (Department of Biotechnology Pukyong National University Busan 48513 Republic of Korea) Lee Eun Ji (Department of Biotechnology Pukyong National University Busan 48513 Republic of Korea) Kim Dong Pil (Department of Biotechnology Pukyong National University Busan 48513 Republic of Korea) Yoon Sun Jay (Department of Biotechnology Pukyong National University Busan 48513 Republic of Korea) Jang Won Je (Department of Biotechnology Pukyong National University Busan 48513 Republic of Korea) Han Sang Jun (Department of Biotechnology Pukyong National University Busan 48513 Republic of Korea) Lee Seungjun (Department of Food Science and Nutrition Pukyong National University Busan 48513 Republic of Korea) Lee Jong Min (Department of Biotechnology Pukyong National University Busan 48513 Republic of Korea)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제33권 제5호
발행연도
2023.5
수록면
621 - 633 (13page)
DOI
10.4014/jmb.2212.12005

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We investigated the probiotic characteristics and anti-obesity effect of Lactiplantibacillus plantarum MGEL20154, a strain that possesses excellent intestinal adhesion and viability. The in vitro properties, e.g., gastrointestinal (GI) resistance, adhesion, and enzyme activity, demonstrated that MGEL20154 is a potential probiotic candidate. Oral administration of MGEL20154 to diet-induced obese C57BL/6J mice for 8 weeks resulted in a feed efficacy decrease by 44.7% compared to that of the high-fat diet (HFD) group. The reduction rate of weight gain was about 48.5% in the HFD+MGEL20154 group compared to that of the HFD group after 8 weeks, and the epididymal fat pad was also reduced in size by 25.2%. In addition, the upregulation of the zo-1, pparα, and erk2, and downregulation of the nf-κb and glut2 genes in Caco-2 cells by MGEL20154 were observed. Therefore, we propose that the anti-obesity effect of the strain is exerted by inhibiting carbohydrate absorption and regulating gene expression in the intestine.

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