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논문 기본 정보

자료유형
학술저널
저자정보
Woo Ga-Eun (Department of Food Science and Technology/Institute of Food Science Pukyong National University Busan 48513 Republic of Korea) Hwang Hye-Ji (Department of Food Science and Technology/Institute of Food Science Pukyong National University Busan 48513 Republic of Korea) Park A-Yeoung (Department of Food Science and Technology/Institute of Food Science Pukyong National University Busan 48513 Republic of Korea) Sim Ji-Yoon (Department of Food Science and Technology/Institute of Food Science Pukyong National University Busan 48513 Republic of Korea) Woo Seon-Young (Department of Food Science and Technology/Institute of Food Science Pukyong National University Busan 48513 Republic of Korea) Kim Min-Ji (Department of Food Science and Technology/Institute of Food Science Pukyong National University Busan 48513 Republic of Korea) Jeong So-Mi (Institute of Fisheries Sciences Pukyong National University Busan 48513 Republic of Korea) Sung Nak-Yun (Division of Natural Product Research Korea Prime Pharmacy CO. LTD. Jeonnam 58144 Korea) Kim Dong-Sub (Division of Natural Product Research Korea Prime Pharmacy CO. LTD. Jeonnam 58144 Korea) Ahn Dong-Hyun (Department of Food Science and Technology/Institute of Food Science Pukyong National University Busan 48513 Republic of Korea)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제33권 제3호
발행연도
2023.3
수록면
363 - 370 (8page)
DOI
10.4014/jmb.2211.11007

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초록· 키워드

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Atopic dermatitis (AD) is a chronic inflammation associated with skin hypersensitivity caused by environmental factors. The objent of this study was to assess the hot water extracts of Sargassum horneri (SHHWE) on AD. AD was induced by spreading 2,4-dinitrochlorobenzene (DNCB) on the BALB/c mice. The efficacy of SHHWE was tested by observing the immunoglobulin E (IgE), cytokine, skin clinical severity score and cytokine secretions in concanavalin A (Con A)-stimulated splenocytes. The levels of interleukine (IL)-4, IL-5 and IgE, the pro-inflammatory cytokines that are closely related, were notably suppressed in a does-dependent manner by SHHWE, whereas the level of interferon γ (IFN-γ), the atopy-related Th1 cytokine inhibiting the production of Th2 cytokines, was increased. Therefore, these results show that SHHWE has a potent anti- inhibitory effect on AD and is highly valuable for cosmetic development.

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