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논문 기본 정보

자료유형
학술저널
저자정보
Jang A-yeong (Department of Marine Bio Food Science, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea) Choi JeongUn (Department of Marine Bio Food Science, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea) Rod-in Weerawan (Department of Marine Bio Food Science, Gangneung-Wonju National University, Gangneung 25457, Republic of KoreaDepartment of Agricultural Science, Faculty of Agriculture Natural Resources and) Choi Ki Young (Department of Marine Bio Food Science, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea) Lee Dae-Hee (Department of Marine Bio Food Science, Gangneung-Wonju National University, Gangneung 25457, Republic of KoreaNbios Inc., Gangneung, Gangwon 25457, Republic of Korea) Park Woo Jung (Department of Marine Bio Food Science, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.4
발행연도
2024.4
수록면
940 - 948 (9page)
DOI
10.4014/jmb.2312.12002

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Codium fragile has been traditionally used in oriental medicine to treat enterobiasis, dropsy, and dysuria, and it has been shown to possess many biological properties. Atopic dermatitis (AD) is one of the types of skin inflammation and barrier disruption, which leads to chronic inflammatory skin diseases. In the current investigation, the protective effects of C. fragile extract (CFE) on antiinflammation and skin barrier improvement were investigated. In LPS-stimulated RAW 264.7 cells, nitric oxide generation and the expression levels of interleukin (IL)-1β, IL-4, IL-6, iNOS, COX-2, and tumor necrosis factor-alpha (TNF)-α were reduced by CFE. CFE also inhibited the phosphorylation of NF-κB-p65, ERK, p-38, and JNK. Additionally, CFE showed inhibitory activity on TSLP and IL-4 expression in HaCaT cells stimulated with TNF-α/interferon- gamma (IFN-γ). Enhanced expression of factors related to skin barrier function, FLG, IVL, and LOR, was confirmed. These findings implied that CFE may be used as a therapeutic agent against AD due to its skin barrier-strengthening and anti-inflammatory activities, which are derived from natural marine products.

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