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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제9호
- 발행연도
- 2020.1
- 수록면
- 1,343 - 1,354 (12page)
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초록· 키워드
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Atopic dermatitis (AD) is a skin disorder that causes chronic itch. We investigated the inhibitory effects of a mixture of prebiotic short-chain galacto-oligosaccharides and long-chain fructooligosaccharides (scGOS/lcFOS), inulin, or β-glucan on AD development in 1-chloro-2,4- dinitrobenzene (DNCB)-treated NC/Nga mice. Mice were randomly assigned to six groups: untreated mice, AD control, positive control (DNCB-treated NC/Nga mice fed a dietary supplement of Zyrtec), and DNCB-treated NC/Nga mice fed a dietary supplement of prebiotics such as scGOS/lcFOS (T1), inulin (T2), or β-glucan (T3). The prebiotic treatment groups (T1, T2, and T3) showed suppression of AD symptoms, Th2 cell differentiation, and AD-like skin lesions induced by DNCB. In addition, prebiotic treatment also reduced the number of microorganisms such as Firmicutes, which is associated with AD symptoms, and increased the levels of Bacteroidetes and Ruminococcaceae, which are associated with alleviation of AD symptoms. Our findings demonstrate the inhibitory effects of prebiotics on AD development by improving the Th1/Th2 cytokine balance and beneficial symbiotic microorganisms in in vitro and in vivo models.
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참고문헌 (56)
참고문헌 신청
Darrigade AS / 2018 / Dual efficacy of dupilumab in a patient with concomitant atopic dermatitis and alopecia areata / Br. J. Dermatol 179:534~536
Palmer CN / 2006 / Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis / Nat. Genet 38:441~446
Gavrilova T / 2018 / Immune dysregulation in the Pathogenesis of atopic dermatitis / Dermatitis 29:57~62
Köberle M / 2018 / Microbiome, atopic eczema and blockade of type 2 immunity / Hautarzt 69:197~203
Barbarot S / 2017 / Physiopathologie de la dermatite atopique : pathophysiology of atopic dermatits / Ann. Dermatol. Venereol 144:14~20
Palmer CN / 2006 / Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis / Nat. Genet 38:441~446
Gavrilova T / 2018 / Immune dysregulation in the Pathogenesis of atopic dermatitis / Dermatitis 29:57~62
Köberle M / 2018 / Microbiome, atopic eczema and blockade of type 2 immunity / Hautarzt 69:197~203
Barbarot S / 2017 / Physiopathologie de la dermatite atopique : pathophysiology of atopic dermatits / Ann. Dermatol. Venereol 144:14~20
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