지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
DBpia Top 1%동일한 주제분류 기준으로최근 2년간 이용수 순으로 정렬했을 때
해당 논문이 위치하는 상위 비율을 의미합니다.
초록· 키워드
오류제보하기
Objectives: Network pharmacology is a method of constructing and analyzing a drug-compound-target network to predict potential efficacy and mechanisms related to drug targets. In that large-scale analysis can be performed in a short time, it is considered a suitable tool to explore the function and role of herbal medicine. Thus, we investigated the potential functions and pathways of Chongmyunggongjin-dan (CMGJD) on Alzheimer’s disease (AD) via network pharmacology analysis.
Methods: Using public databases and PubChem database, compounds of CMGJD and their target genes were collected. The putative target genes of CMGJD and known target genes of AD were compared and found the correlation. Then, the network was constructed using Cytoscape 3.9.1. and functional enrichment analysis was conducted based on the Gene Ontology (GO) Biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways to predict the mechanisms.
Results: The result showed that total 104 compounds and 1157 related genes were gathered from CMGJD. The network consisted of 1157nodes and 10034 edges. 859 genes were interacted with AD gene set, suggesting that the effects of CMGJD are closely related to AD. Target genes of CMGJD are considerably associated with various pathways including ‘Positive regulation of chemokine production’, ‘Cellular response to toxic substance’, ‘Arachidonic acid metabolic process’, ‘PI3K-Akt signaling pathway’, ‘Metabolic pathways’, ‘IL-17 signaling pathway’ and ‘Neuroactive ligand-receptor interaction’.
Conclusion: Through a network pharmacological method, CMGJD was predicted to have high relevance with AD by regulating inflammation. This study could be used as a basis for effects of CMGJD on AD.
Methods: Using public databases and PubChem database, compounds of CMGJD and their target genes were collected. The putative target genes of CMGJD and known target genes of AD were compared and found the correlation. Then, the network was constructed using Cytoscape 3.9.1. and functional enrichment analysis was conducted based on the Gene Ontology (GO) Biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways to predict the mechanisms.
Results: The result showed that total 104 compounds and 1157 related genes were gathered from CMGJD. The network consisted of 1157nodes and 10034 edges. 859 genes were interacted with AD gene set, suggesting that the effects of CMGJD are closely related to AD. Target genes of CMGJD are considerably associated with various pathways including ‘Positive regulation of chemokine production’, ‘Cellular response to toxic substance’, ‘Arachidonic acid metabolic process’, ‘PI3K-Akt signaling pathway’, ‘Metabolic pathways’, ‘IL-17 signaling pathway’ and ‘Neuroactive ligand-receptor interaction’.
Conclusion: Through a network pharmacological method, CMGJD was predicted to have high relevance with AD by regulating inflammation. This study could be used as a basis for effects of CMGJD on AD.
목차
서론
방법
결과
고찰
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
H2O2로 유발된 C6 신경교세포 사멸에 대한 총명공진단의 보호 효과
대한한방내과학회지
2020 .01
-
벌사상자의 위염 치료 적용에 대한 네트워크 약리학적 분석
동의생리병리학회지
2024 .02
-
Profiling of remote skeletal muscle gene changes resulting from stimulation of atopic dermatitis disease in NC/Nga mouse model
The Korean Journal of Physiology & Pharmacology
2019 .01
-
Analysis of the mechanism of fibrauretine alleviating Alzheimer's disease based on transcriptomics and proteomics
The Korean Journal of Physiology & Pharmacology
2024 .07
-
네트워크 약리학을 기반으로 한 이진탕의 구성성분과 동맥경화 타겟 유전자의 효능 예측
한약정보연구회지
2017 .11
-
Survival Analysis of Patients with Alzheimer’s Disease: A Study Based on Data from the Korean National Health Insurance Services’ Senior Cohort Database
Korean Journal of Family Medicine
2020 .01
-
Metabolism-Centric Overview of the Pathogenesis of Alzheimer’s Disease
Yonsei Medical Journal
2017 .01
-
네트워크 약리학적 접근을 통한 대황목단피탕(大黃牧丹皮湯)의 당뇨병성 인지장애 조절 가능성 및 기전 탐색
대한한의학회지
2024 .06
-
Brain Region-Dependent Alternative Splicing of Alzheimer Disease (AD)-Risk Genes Is Associated With Neuropathological Features in AD
International Neurourology Journal
2022 .11
-
네크워크 약리학적 방법론을 활용한 한의학 효능 연구 고찰
동의생리병리학회지
2016 .12
-
네크워크 약리학적 방법론을 활용한 한의학 효능 연구 고찰
동의생리병리학회지
2016 .01
-
Therapeutic New Era for Atopic Dermatitis: Part 1. Biologics
Annals of Dermatology
2021 .01
-
Clinical Characteristics and Genetic Variations in Early-Onset Atopic Dermatitis Patients
Annals of Dermatology
2019 .01
-
Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population
Cancer Research and Treatment
2024 .01
-
한의학 연구에 활용되는 네트워크 약리학 데이터베이스들의 특성 비교 : 대표적 시나리오 중심으로
동의생리병리학회지
2024 .10
-
Association of Alzheimer's Disease with the Risk of Developing Epilepsy: a 10-Year Nationwide Cohort Study
Dementia and Neurocognitive Disorders(대한치매학회지)
2018 .01
-
알츠하이머병 환자에서 해마 위축과 정신병적 증상
신경정신의학
2018 .01
-
Stem Cell Therapy: A Prospective Treatment for Alzheimer’s Disease
PSYCHIATRY INVESTIGATION
2016 .01
-
A Review on the Correlation between the Pathology of Alzheimer"s Disease and microRNA
대한의생명과학회지
2021 .12
-
Diagnostic Tools for Alzheimer’s Disease: A Narrative Review Based on Our Own Research Experience
Dementia and Neurocognitive Disorders(대한치매학회지)
2023 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
한의학 이론 연구를 위한 새로운 방법: 네트워크 약리학을 활용한 약물중심 접근법
이원융
,
김창업
,
이충열
동의생리병리학회지
2021
.10
질병의 치료를 위한 유전자 조작 미생물 의약품 개발 동향
송미령
BT NEWS
2023
.04
일부 대학생들의 시험 유무에 따른 카페인 섭취와 식이장애 분석
이은지
,
정복미
한국지역사회생활과학회지
2023
.02
알츠하이머 치매 환자에서 치료 전 중증도에 따른 약물의 장기 치료 효과
서희원
,
박유리
,
권인선
외 1명
생물치료정신의학
2021
.02
공정무역커피 브랜드 인지도와 브랜드 이미지가 구매의도에 미치는 영향
고미애
,
김지연
관광연구저널
2015
.05
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-519-001478460