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A Novel Method to Investigating Korean Medicine Theory: Drug-centered Approach Employing Network Pharmacology
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한의학 이론 연구를 위한 새로운 방법: 네트워크 약리학을 활용한 약물중심 접근법

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Type
Academic journal
Author
Won Yung Lee (가천대학교) Chang Eop Kim (가천대학교) Choong Yeol Lee (가천대학교)
Journal
The Society of Pathology in Korean Medicine Journal of Physiology & Pathology in Korean Medicine Vol.35 No.5 KCI Accredited Journals
Published
2021.10
Pages
125 - 131 (7page)
DOI
10.15188/kjopp.2021.10.35.5.125

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A Novel Method to Investigating Korean Medicine Theory: Drug-centered Approach Employing Network Pharmacology
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The scientific understanding of Korean medicine theory remains largely unknown, since there is a lack of proper methods to investigate its complex and unique characteristics. Here, we introduce a drug-centered approach, a novel method to investigate Korean medicine theory by analyzing the mechanisms of herbal medicines. This method can be effectively conducted by employing network pharmacology that can analyze the systems-level mechanisms of herbal medicines on a large scale. Firstly, we introduce the method of network pharmacology that are applied to analyze the mechanisms of herbal medicines in a step-by-step manner. Then, we show how the drug-centered approach employing network pharmacology can be applied to investigate Korean medicine theory by describing studies that identify the biological correlates of the cold-hot nature of herbs, spleen qi deficiency syndrome, or Sasang constitution. Finally, we discuss the limitations and future directions of the proposed approach in two aspects: The methods of network pharmacology for a drug-centered approach and the process of inferring Korean medicine theory through it. We believe that a drug-centered approach employing network pharmacology will provide an advanced scientific understanding of Korean medicine theory and contribute to its development by generating biologically plausible hypothesis.
#Korean medicine theory #Network pharmacology #Drug-centered approach

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References (32)

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이수진 / 2016 / 시스템 생리학에 기반한 한열 변증의 이해 / 동의생리병리학회지 30(6):376~384 Crossref Moncrieff J / 2018 / Research on a"drug-centred"approach to psychiatric drug treatment : Assessing the impact of mental and behavioural alterations produced by psychiatric drugs / Epidemiol Psychiatr Sci 27(2):133~140 google schola Zhang R / 2019 / Network Pharmacology Databases for Traditional Chinese Medicine : Review and Assessment / Front Pharmacol 10(123):1~14 google schola Hopkins AL / 2007 / Network pharmacology / Nature Biotechnology google schola Lee WY / 2019 / The methodological trends of traditional herbal medicine employing network pharmacology / Biomolecules 9(8):362 google schola

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