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Objectives: This study was conducted to identify the protective effects of Chongmyunggongjin-dan (CMGJD) on Hydrogen peroxide (H2O2)-induced apoptosis mechanisms in C6 glial cells. Method: We used CMGJD after distilled water extraction, filtration, and lyophilization. The ROS scavenging effect was examined by fluorescence microscopy. Expression levels of proteins related to ROS generation were investigated by western blotting. Functional changes in organelles related to Reactive oxygen species (ROS) generation were investigated by immunoblotting and by verifying expression level of relevant enzymes. Results: The CMGJD extract protected the cells against H2O2-induced morphological changes and DNA fragmentation, inhibited the increase of Heme_oxygenase-1(HO-1) and the decrease in catalase, protected against the loss of mitochondrial membrane potential, inhibited disturbances of lysosomal function, and induced an increase in peroxisomes. Conclusion: CMGJD was confirmed to have a protective effect on H2O2-induced C6 glial cell death possibly by blocking the pathways causing damage to subcellular organelles, such as mitochondria, lysosomes, and peroxisomes. We assume that CMGJD will be effective for the prevention and treatment of ischemic stroke in a clinical environment.
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참고문헌 (39)
참고문헌 신청
전국 한의과대학 심계내과학 교수협의회 / 2016 / 한방. 순환⋅신경내과학 신경계 편 / 우리의학서적 :80~84
Jameson JL / 2018 / Harrison's principles of internal medicine / McGraw-Hill Education :3079~3080
Lipton P / 1999 / Ischemic Cell Death in Brain Neurons / Physiol Review 79(4):1499
Iwata-Ichikawa E / 1999 / Glial Cells Protect Neurons Against Oxidative Stress via Transcriptional Up-Regulation of the Glutathione Synthesis / Journal of Neurochemistry 72(6):2334~2344
王璆 / 1991 / 是齋百一選方 / 상해과학기술출판사 :280
Jameson JL / 2018 / Harrison's principles of internal medicine / McGraw-Hill Education :3079~3080
Lipton P / 1999 / Ischemic Cell Death in Brain Neurons / Physiol Review 79(4):1499
Iwata-Ichikawa E / 1999 / Glial Cells Protect Neurons Against Oxidative Stress via Transcriptional Up-Regulation of the Glutathione Synthesis / Journal of Neurochemistry 72(6):2334~2344
王璆 / 1991 / 是齋百一選方 / 상해과학기술출판사 :280
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