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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 58 - 64 (7page)
- DOI
- http://dx.doi.org/10.13041/jpvm.2015.39.2.58
이용수
초록· 키워드
오류제보하기
This study was conducted to evaluate the accumulation and distribution of HGC (hydrophobically modified glycol chitosan) as a degradable nanoparticle in the body. To determine the movement of degradable HGC nanoparticles in the body, 20 mg/kg of lutetium177-labeled HGC (Lu177-HGC) with a size range from 320 to 400 nm was injected intravenously into ICR mice, and the amount of radioactivity remaining in blood and several organs was measured at various time points a period of 5 days. In the pharmacokinetics analysis using the Lu177 radioisotope, the free Lu177 was mainly distributed and accumulated in the order of kidney>liver>lung at 1 day after the injection of radioisotope. However, the Lu177-HGC showed a high distribution of nanoparticles in the order of liver>spleen>kidney until 5 days. These results would provide a basic pharmacokinetics for the use of HGC as a drug carrier in drug delivery system.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Cho M / 2009 / The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles / Toxicol Lett 189(3):177~183
Cho WS / 2009 / Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles / Toxicol Appl Pharmacol 236(1):16~24
Choi HS / 2007 / Renal clearance of quantum dots / Nat Biotechnol 25(10):1165~1170
Demoy M / 1999 / Spleen capture of nanoparticles: influence of animal species and surface characteristics / Pharm Res 16(1):37~41
Desai MP / 1996 / Gastrointestinal uptake of biodegradable microparticles:effect of particle size / Pharm Res 13(12):1838~1845
Cho WS / 2009 / Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles / Toxicol Appl Pharmacol 236(1):16~24
Choi HS / 2007 / Renal clearance of quantum dots / Nat Biotechnol 25(10):1165~1170
Demoy M / 1999 / Spleen capture of nanoparticles: influence of animal species and surface characteristics / Pharm Res 16(1):37~41
Desai MP / 1996 / Gastrointestinal uptake of biodegradable microparticles:effect of particle size / Pharm Res 13(12):1838~1845
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