지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 70 - 76 (7page)
- DOI
- https://doi.org/10.14449/jbd.2016.4.2.70
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초록· 키워드
오류제보하기
Purpose: The preoperative determination of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), and Ki-67 expression status is crucial because these factors influence the therapeutic response to endocrine therapy, chemotherapy, and HER2-targeted therapy and help in the selection of adjuvant or neoadjuvant treatment. To evaluate the accuracy of core needle biopsy (CNB) in determining ER, PR, and HER2 status, and Ki-67 level status, we compared the results of CNB with those of surgical specimens. Methods: We retrospectively reviewed data from 191 patients with breast cancer whose ER, PR, and HER2 status, and Ki-67 level status was analyzed using both CNB and surgical specimens between 2013 and 2015. Patients who received neoadjuvant chemotherapy were excluded from this study. ER, PR, and Ki-67 were detected using immunohistochemistry (IHC) and reported as the percentage of positively stained cells. The cutoff point was 1% for ER and PR, and 14% for Ki-67. HER2 was determined by IHC and/or fluorescence in situ hybridization (FISH). HER2 positivity was defined as IHC 3+ or FISH (+). Results: In correlation analysis, Pearson correlation coefficients were 0.950 for ER expression, 0.813 for PR expression, 0.847 for HER2 grade, and 0.817 for Ki-67 expression level (p<0.0001). According to criteria for ER, PR, HER2, and Ki-67, the sensitivities of ER, PR, HER2, and Ki-67 assessment in CNB were 92.6%, 88.8%, 100%, and 80.6%, respectively. The specificities of ER, PR, HER2, and Ki-67 assessments in CNB were 90.7%, 86.0%, 99.1%, and 88.7%, respectively. Conclusion: The ER, PR, HER2, and Ki-67 status in CNB specimens correlated well with their status in surgical specimens. The HER2 status was the most accurately assessed factor in CNB specimens when compared to its assessment in surgical specimens. However, Ki-67 levels in CNB specimens were lower than those in surgical specimens.
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참고문헌 (28)
참고문헌 신청
Perou CM / 2000 / Molecular portraits of human breast tumours / Nature 406:747~752
Sørlie T / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98:10869~10874
Goldhirsch A / 2011 / Strategies for subtypes–dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011 / Ann Oncol 22:1736~1747
de Azambuja E / 2007 / Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients / Br J Cancer 96:1504~1513
Jones RL / 2009 / The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer / Breast Cancer Res Treat 116:53~68
Sørlie T / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98:10869~10874
Goldhirsch A / 2011 / Strategies for subtypes–dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011 / Ann Oncol 22:1736~1747
de Azambuja E / 2007 / Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients / Br J Cancer 96:1504~1513
Jones RL / 2009 / The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer / Breast Cancer Res Treat 116:53~68
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