지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제53권 제4호
- 발행연도
- 2019.1
- 수록면
- 236 - 243 (8page)
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초록· 키워드
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Background: Although primary cancer of the fallopian tubes is a relatively rare type of tumor in female reproductive organs, its mortality is quite high. It is important to identify molecular and biological markers of this malignancy that determine its specific phenotype. Methods: The study was carried out on samples received from 71 female patients with primary cancer of the fallopian tubes. The main molecular and biological properties, including hormone status (estrogen receptor [ER], progesterone receptor [PR]), human epidermal growth factor receptor (HER2)/neu expression, proliferative potential (Ki-67), apoptosis (p53, Bcl-2), and pro-angiogenic (vascular endothelial growth factor) quality of serous tumors were studied in comparison with clinical and morphological characteristics. Results: ER and PR expression is accompanied by low grade neoplasia, early clinical disease stage, and absence of lymphogenic metastasis (p < .001). HER2/neu expression is not typical for primary cancer of the fallopian tubes. Ki-67 expression is characterized by an inverse correlation with ER and PR (p < .05) and is associated with lymphogenic metastasis (p < .01). p53+ status correlates with high grade malignancy, tumor progression, metastasis, negative ER/PR (p < .001), and negative Bcl-2 status (p < .05). Positive Bcl-2 status is positively correlated with ER and PR expression and low grade malignancy. Conclusions: Complex morphologic (histological and immunohistochemical) study of postoperative material allows estimation of the degree of malignancy and tumor spread to enable appropriate treatment for each case.
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참고문헌 (31)
참고문헌 신청
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Azodi M / 2000 / Primary fallopian tube carcinoma with isolated torsion of involved tube / Eur J Gynaecol Oncol 21:364~367
Singhal P / 2006 / Primary fallopian tube carcinoma : a retrospective clinicopathologic study / Eur J Gynaecol Oncol 27:16~18
Kalampokas E / 2014 / Primary fallopian tube carcinoma : a case report and mini-review of the literature / Eur J Gynaecol Oncol 35:595~596
Riska A / 2007 / Updating on primary fallopian tube carcinoma / Acta Obstet Gynecol Scand 86:1419~1426
Azodi M / 2000 / Primary fallopian tube carcinoma with isolated torsion of involved tube / Eur J Gynaecol Oncol 21:364~367
Singhal P / 2006 / Primary fallopian tube carcinoma : a retrospective clinicopathologic study / Eur J Gynaecol Oncol 27:16~18
Kalampokas E / 2014 / Primary fallopian tube carcinoma : a case report and mini-review of the literature / Eur J Gynaecol Oncol 35:595~596
Riska A / 2007 / Updating on primary fallopian tube carcinoma / Acta Obstet Gynecol Scand 86:1419~1426
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