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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제1호
- 발행연도
- 2020.1
- 수록면
- 87 - 94 (8page)
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Background: Accurate molecular classification of breast core needle biopsy (CNB) tissue is important for determining neoadjuvant systemic therapies for invasive breast cancer. The researchers aimed to evaluate the concordance rate (CR) of molecular subtypes between CNBs and surgical specimens. Methods: This study was conducted with invasive breast cancer patients who underwent surgery after CNB at Seoul St. Mary’s Hospital between December 2014 and December 2017. Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki67 were analyzed using immunohistochemistry. ER and PR were evaluated by Allred score (0–8). HER2 was graded from 0 to +3, and all 2+ cases were reflex tested with silver in situ hybridization. The labeling index of Ki67 was counted by either manual scoring or digital image analysis. Molecular subtypes were classified using the above surrogate markers. Results: In total, 629 patients were evaluated. The CRs of ER, PR, HER2, and Ki67 were 96.5% (kappa, 0.883; p < .001), 93.0% (kappa, 0.824; p < .001), 99.7% (kappa, 0.988; p < .001), and 78.7% (kappa, 0.577; p < .001), respectively. Digital image analysis of Ki67 in CNB showed better concordance with Ki67 in surgical specimens (CR, 82.3%; kappa, 0.639 for digital image analysis vs. CR, 76.2%; kappa, 0.534 for manual counting). The CRs of luminal A, luminal B, HER2, and triple negative types were 89.0%, 70.0%, 82.9%, and 77.2%, respectively. Conclusions: CNB was reasonably accurate for determining ER, PR, HER2, Ki67, and molecular subtypes. Using digital image analysis for Ki67 in CNB produced more accurate molecular classifications.
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참고문헌 (34)
참고문헌 신청
Cheang MC / 2009 / Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer / J Natl Cancer Inst 101:736~750
Goldhirsch A / 2013 / Personalizing the treatment of women with early breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24:2206~2223
Goldhirsch A / 2011 / Strategies for subtypes:dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011 / Ann Oncol 22:1736~1747
Neubauer H / 2008 / Changes in tumour biological markers during primary systemic chemotherapy(PST) / Anticancer Res 28:1797~1804
Untch M / 2014 / Current and future role of neoadjuvant therapy for breast cancer / Breast 23:526~537
Goldhirsch A / 2013 / Personalizing the treatment of women with early breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24:2206~2223
Goldhirsch A / 2011 / Strategies for subtypes:dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011 / Ann Oncol 22:1736~1747
Neubauer H / 2008 / Changes in tumour biological markers during primary systemic chemotherapy(PST) / Anticancer Res 28:1797~1804
Untch M / 2014 / Current and future role of neoadjuvant therapy for breast cancer / Breast 23:526~537
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