The Effect of Cold Ischemic Time on Immunohistochemical Evaluation of Invasive Ductal Carcinoma

Hye Jin Kim; Han-Byoel Lee; Tae-Kyung Yoo; Jongjin Kim; Young-Joon Kang; Jaihong Han; Yumi Kim; Hyeong-Gon Moon; Wonshik Han; Dong-Young Noh

doi:http://dx.doi.org/10.14449/jbd.2015.3.2.60

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자료유형: 학술저널

저자정보: Hye Jin Kim (Department of Surgery Seoul National University College of Medicine) Han-Byoel Lee (Department of Surgery Seoul National University College of Medicine) Tae-Kyung Yoo (Department of Surgery Seoul National University College of Medicine) Jongjin Kim (Department of Surgery Boramae Medical Center) Young-Joon Kang (Department of Surgery Seoul National University College of Medicine) Jaihong Han (Department of Surgery Seoul National University College of Medicine) Yumi Kim (Department of Surgery Seoul National University College of Medicine) Hyeong-Gon Moon (Department of Surgery Seoul National University College of MedicineCancer Research Institute Seoul) Wonshik Han (Department of Surgery Seoul National University College of Medicine Cancer Research Institute Seoul) Dong-Young Noh (Department of Surgery Seoul National University College of Medicine Cancer Research Institute Seoul)

저널정보: 한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제3권 제2호

발행연도: 2015.12

수록면: 60 - 64 (5page)

DOI: http://dx.doi.org/10.14449/jbd.2015.3.2.60

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Purpose: Immunohistochemical (IHC) evaluation is important for the management of breast cancer. Cold ischemic time (CIT) may result in inaccurate IHC results. The aim of this study was to investigate the effect of CIT on IHC results of invasive ductal carcinoma (IDC). Methods: We retrospectively reviewed the records of 316 patients diagnosed with IDC from February 2013 to June 2013 at a single hospital in Korea. The clinicopathological characteristics and IHC positivity for the estrogen receptor (ER), progesterone receptor (PR), Ki-67, and human epidermal growth factor receptor 2 (HER2) were compared between specimens with a CIT of ≤3 hours (short CIT) and those with a CIT of >12 hours (long CIT). Results: Among the 316 patients, 227 had a CIT of ≤3 hours and 89 had a CIT of >12 hours. No difference in positivity for ER (p=0.734), PR (p=0.870), and HER2 (p=0.830) was observed between the two groups. In ER-positive specimens, the mean percentage value was higher in the long CIT group than in the short CIT group (81.3±20.8% vs. 76.0±26.3%, respectively; p=0.021). The mean Ki-67 value was higher in the long CIT group compared to the short CIT group (9.7±14.6% vs. 7.0±10.8%, respectively; p=0.047). Conclusion: CIT did not affect the positivity of ER, PR, HER2, and Ki-67 as determined by IHC when stored at 4°C overnight. However, specimens with a long CIT had a higher ER percentage value in ER-positive tumors and a higher Ki-67 value in all specimens compared to those with a short CIT. These differences should be considered in the interpretation of IHC results in specimens with a long CIT.

#Breast neoplasms #Cold ischemia #Immunohistochemistry

참고문헌 (16)

참고문헌 신청

Early Breast Cancer Trialists’ Collaborative Group / 1998 / Tamoxifen for early breast cancer: an overview of the randomised trials / Lancet 351:1451~1467

Tan AR / 2003 / Ongoing adjuvant trials with trastuzumab in breast cancer / Semin Oncol 30(5 Suppl 16):54~64

Zaha DC / 2014 / Significance of immunohistochemistry in breast cancer / World J Clin Oncol 5:382~392

Zhao L / 2014 / Diagnostic role of immunohistochemistry in the evaluation of breast pathology specimens / Arch Pathol Lab Med 138:16~24

Cuzick J / 2011 / Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer / J Clin Oncol 29:4273~4278

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