Immunohistochemical analysis of estrogen receptors in prostate and clinical correlation in men with benign prostatic hyperplasia

Goto Gangkak; Rohit Bhattar; Alka Mittal; Sher Singh Yadav; Vinay Tomar; Ajay Yadav; Jayanti Mehta

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자료유형: 학술저널

저자정보: Goto Gangkak (SMS Medical College & Attached Hospitals) Rohit Bhattar (SMS Medical College & Attached Hospitals) Alka Mittal (SMS Medical College & Attached Hospitals) Sher Singh Yadav (SMS Medical College & Attached Hospitals) Vinay Tomar (SMS Medical College & Attached Hospitals) Ajay Yadav (SMS Medical College & Attached Hospitals) Jayanti Mehta (SMS Medical College & Attached Hospitals)

저널정보: 대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.58 No.2

발행연도: 2017.1

수록면: 117 - 126 (10page)

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Purpose: Estrogens act through interaction with 2 receptor subtypes, ER alpha (ERα) and ER beta (ERβ), in human prostate. The aim of the present study was to semiquantitatively assess the differential expression of ER subtypes in human benign prostatic hyperplasia (BPH) by use of immunocytochemistry (IHC) methods and to explore their relationship with various measures of BPH. Materials and Methods: A total of 45 patients with BPH undergoing transurethral resection of the prostate and 22 patients with bladder cancer with normal prostate undergoing surveillance cystoscopy were studied as cases and controls, respectively. Quantitative immunolabeling of ER subtypes was scored by use of a semiquantitative scale. Also, correlations were assessed between ER levels in prostate and various measures of BPH. Results: Overall, we found strong immunostaining for ERα in stroma and for ERβ in epithelium, respectively. The IHC score for ERα differed significantly between BPH patients and controls in both stroma (p≤0.001) and epithelium (p=0.008), respectively. The ERβ IHC score was also significantly higher in the epithelium of BPH patients (p=0.01). Also, we found a significant correlation between prostatic ER levels and various clinical measures of BPH. Conclusions: ERs may play an important role in the pathogenesis of BPH.

참고문헌 (30)

참고문헌 신청

Barry MJ / 1990 / Epidemiology and natural history of benign prostatic hyperplasia / Urol Clin North Am 17:495~507

Castagnetta LA / 1995 / Nonreproductive actions of sex steroids / John Wiley Sons :269~289

Prins GS / 2008 / The role of estrogens and estrogen receptors in normal prostate growth and disease / Steroids 73:233~244

Risbridger GP / 2003 / Oestrogens and prostate cancer / Endocr Relat Cancer 10:187~191

Greene GL / 1986 / Sequence and expression of human estrogen receptor complementary DNA / Science 231:1150~1154

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