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논문 기본 정보

자료유형
학술저널
저자정보
Young-Su Yi (Cheongju University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.43 No.2
발행연도
2019.4
수록면
172 - 178 (7page)

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초록· 키워드

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Inflammation is an innate immune response that protects the body from pathogens, toxins, and other dangers and is initiated by recognizing pathogen-associated molecular patterns or danger-associated molecular patterns by pattern-recognition receptors expressing on or in immune cells. Intracellular pattern-recognition receptors, including nucleotide-binding oligomerization domain-like receptors (NLRs), absent in melanoma 2, and cysteine aspartateespecific protease (caspase)-4/5/11 recognize various pathogen-associated molecular patterns and danger-associated molecular patterns and assemble protein complexes called “inflammasomes.” These complexes induce inflammatory responses by activating a downstream effector, caspase-1, leading to gasdermin D emediated pyroptosis and the secretion of proinflammatory cytokines, such as interleukin (IL)-1b and IL-18. Ginsenosides are natural steroid glycosides and triterpene saponins found exclusively in the plant genus Panax. Various ginsenosides have been identified, and their abilities to regulate inflammatory responses have been evaluated. These studies have suggested a link between ginsenosides and inflammasome activation in inflammatory responses. Some types of ginsenosides, including Rh1, Rg3, Rb1, compound K, chikusetsu saponin IVa, Rg5, and Rg1, have been clearly demonstrated to inhibit inflammatory responses by suppressing the activation of various inflammasomes, including the NLRP3, NLRP1, and absent in melanoma 2 inflammasomes. Ginsenosides have also been shown to inhibit caspase-1 and to decrease the expression of IL-1b and IL-18. Given this body of evidence, the functional relationship between ginsenosides and inflammasome activation provides new insight into the understanding of the molecular mechanisms of ginsenosidemediated antiinflammatory actions. This relationship also has applications regarding the development of antiinflammatory remedies by ginsenoside-mediated targeting of inflammasomes, which could be used to prevent and treat inflammatory diseases.

목차

ABSTRACT
1. Introduction
2. Types of inflammasomes: structure and activation
3. Roles of ginsenosides in inflammasome activation
4. Conclusion
References

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