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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 111 - 116 (6page)
- DOI
- http://dx.doi.org/10.11620/IJOB.2015.40.3.111
이용수
초록· 키워드
오류제보하기
To determine the effect of diabetes on root resorption in periodontitis, we investigated odontoclast formation and root resorption in diabetic rats with periodontitis. Odontoclast formation was observed in three groups of F344 rats: Controls (C) were normal rats without diabetes or periodontitis; the periodontitis (P) group had mandibular first molars to be ligatured; the periodontitis with diabetes (PD) group was intravenously administered streptozotocin (50 mg/kg) to induce diabetes and had mandibular first molars to be ligatured. On days 3, 10, and 20 after ligature, tumor necrosis factor (TNF)-α and receptor activator of nuclear factor-κB ligand (RANKL) expression, odontoclast formation, and root resorption areas were evaluated by immunohistochemistry, tartrate-resistant acid phosphatase staining, and hematoxylin and eosin staining, respectively. The PD group showed frequent urination, weight loss, and hyperglycemia. Numbers of TNF-α- and RANKL-positive cells were higher in the P and PD groups than in the C group. It was more prevalent in PD group on day 3. Odontoclast formation was greater in the P and PD groups than in the C group on days 3 and 10, then decreased to same level as the C group by day 20. Root resorption in the PD and P groups showed increases on days 3 and 10, respectively, compared to the C group. These results suggest that diabetes may transiently increase root resorption on day 3 with high expression of TNF-α and RANKL after periodontitis induction. This study could aid the understanding of root resorption in diabetic patients with periodontitis.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Fuss Z / 2003 / Root resorption-diagnosis, classification and treatment choices based on stimulation factors / Dent Traumatol 19:175~182
Harokopakis-Hajishengallis E / 2007 / Physiologic root resorption in primary teeth : molecular and histological events / J Oral Sci 49:1~12
Crespo Abelleira AC / 1999 / Morphological study of root surfaces in teeth with adult periodontitis / J Periodontol 70:1283~1291
Harvey BL / 1959 / Root surface resorption of periodontally diseased teeth / Oral Surg Oral Med Oral Pathol 12:1439~1443
Rodriguez-Pato RB / 2004 / Root resorption in chronic periodontitis : a morphometrical study / J Periodontol 75:1027~1032
Harokopakis-Hajishengallis E / 2007 / Physiologic root resorption in primary teeth : molecular and histological events / J Oral Sci 49:1~12
Crespo Abelleira AC / 1999 / Morphological study of root surfaces in teeth with adult periodontitis / J Periodontol 70:1283~1291
Harvey BL / 1959 / Root surface resorption of periodontally diseased teeth / Oral Surg Oral Med Oral Pathol 12:1439~1443
Rodriguez-Pato RB / 2004 / Root resorption in chronic periodontitis : a morphometrical study / J Periodontol 75:1027~1032
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