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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 92 - 98 (7page)
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초록· 키워드
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Periodontitis is a bacteria-induced inflammatory disease associated with alveolar bone loss. Osteoclast is amacrophage-lineage cell that exhibits phagocytic activity; however, osteoclast phagocytic activity has not beendemonstrated under pathological conditions. Diabetes is a pathological condition that exacerbates alveolar bone lossvia periodontitis; therefore, we examined phagocytic osteoclasts in diabetic rats that had periodontitis. The rats weredivided into the control (C), periodontitis (P), and diabetes with periodontitis (DP) groups. Diabetes and periodontitiswere induced by streptozotocin injection and ligature of the mandibular first molars, respectively. On days 3 and 20after the ligature, the rats were sacrificed, and osteoclasts containing inclusions were quantified by tartrate-resistantacid phosphatase staining. On day 3, there were more osteoclasts containing inclusions in the DP group than in the Cgroup. Among inclusions, osteocyte-like cells and dense bodies were more frequently observed in the DP group thanin the C group. Cytoplasm-like structures were elevated more in the DP group than in the C and P groups. However,no differences were observed on day 20. Interestingly, some osteoclasts were in contact with the osteocytes withinthe exposed lacunae and contained several inclusions within a large vacuole. Thus, the elevation of phagocyticosteoclasts in rats with diabetes and periodontitis provides insight into the role of osteoclast phagocytic activity underpathological conditions.
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참고문헌 (20)
참고문헌 신청
Deborah Veis Novack / 2016 / Osteoclasts—Key Players in Skeletal Health and Disease / Microbiology Spectrum 4(3)
W.A. Soskolne / 1978 / Phagocytosis of osteocytes by osteoclasts in femora of two week-old rabbits / Cell and Tissue Research 195(3):557~564
Bargsten G / 1985 / Light and electron microscopic study on the osteoclastic phagocytosis of cells in the rat / Anat Anz 159:13~20
A. S. Elmardi / 1990 / Electron microscopy of developing calvaria reveals images that suggest that osteoclasts engulf and destroy osteocytes during bone resorption / Calcified Tissue International 46(4):239~245
F. Boabaid / 2001 / Apoptotic bone cells may be engulfed by osteoclasts during alveolar bone resorption in young rats / Tissue and Cell 33(4):318~325
W.A. Soskolne / 1978 / Phagocytosis of osteocytes by osteoclasts in femora of two week-old rabbits / Cell and Tissue Research 195(3):557~564
Bargsten G / 1985 / Light and electron microscopic study on the osteoclastic phagocytosis of cells in the rat / Anat Anz 159:13~20
A. S. Elmardi / 1990 / Electron microscopy of developing calvaria reveals images that suggest that osteoclasts engulf and destroy osteocytes during bone resorption / Calcified Tissue International 46(4):239~245
F. Boabaid / 2001 / Apoptotic bone cells may be engulfed by osteoclasts during alveolar bone resorption in young rats / Tissue and Cell 33(4):318~325
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