Effect of caspases and RANKL induced by heavy force in orthodontic root resorption

Yukari Minato; Masaru Yamaguchi; Mami Shimizu; Jun Kikuta; Takuji Hikida; Momoko Hikida; Masaaki Suemitsu; Kayo Kuyama; Kazutaka Kasai

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자료유형: 학술저널

저자정보: Yukari Minato (Nihon University School of Dentistry) Masaru Yamaguchi (Nihon University School of Dentistry) Mami Shimizu (Nihon University School of Dentistry) Jun Kikuta (Nihon University School of Dentistry) Takuji Hikida (Nihon University School of Dentistry) Momoko Hikida (Nihon University School of Dentistry) Masaaki Suemitsu (Nihon University School of Dentistry) Kayo Kuyama (Nihon University School of Dentistry) Kazutaka Kasai (Nihon University School of Dentistry)

저널정보: 대한치과교정학회 대한치과교정학회지 대한치과교정학회지 제48권 제4호

발행연도: 2018.7

수록면: 253 - 261 (9page)

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Objective: Orthodontic root resorption (ORR) due to orthodontic tooth movement is a difficult treatment-related adverse event. Caspases are important effector molecules for apoptosis. At present, little is known about the mechanisms underlying ORR and apoptosis in the cementum. The aim of the present in vivo study was to investigate the expression of tartrate-resistant acid phosphatase (TRAP), caspase 3, caspase 8, and receptor activator of nuclear factor kappa-B ligand (RANKL) in the cementum in response to a heavy or an optimum orthodontic force. Methods: The maxillary molars of male Wistar rats were subjected to an orthodontic force of 10 g or 50 g using a closed coil spring. The rats were sacrificed each experimental period on days 1, 3, 5, and 7 after orthodontic force application. And the rats were subjected to histopathological and immunohistochemical analyses. Results: On day 7 for the 50-g group, hematoxylin and eosin staining revealed numerous root resorption lacunae with odontoclasts on the root, while immunohistochemistry showed increased TRAP- and RANKL-positive cells. Caspase 3- and caspase 8-positive cells were increased on the cementum surfaces in the 50-g group on days 3 and 5. Moreover, the number of caspase 3- and caspase 8-positive cells and RANKLpositive cells was significantly higher in the 50-g group than in the 10-g group. Conclusions: In our rat model, ORR occurred after apoptosis was induced in the cementum by a heavy orthodontic force. These findings suggest that apoptosis of cementoblasts is involved in ORR.

#Apoptosis #Caspase #Receptor activator of nuclear factor kappa-B ligand #Root resorption

참고문헌 (28)

참고문헌 신청

[학술지(정기간행물)] - Kaley J / 1991 / Factors related to root resorption in edgewise practice / Angle Orthod 61 : 125 ~ 132

[학술지(정기간행물)] - Linge BO / 1983 / Apical root resorption in upper anterior teeth / Eur J Orthod 5 : 173 ~ 183

[학술지(정기간행물)] - Owman-Moll P / 1996 / The effects of a four-fold increased orthodontic force magnitudeon tooth movement and root resorptions. An intraindividual study in adolescents / Eur J Orthod 18 : 287 ~ 294

[학술지(정기간행물)] - Owman-Moll P / 1996 / Effects of a doubled orthodontic force magnitude on tooth movement and root resorptions. An inter-individual study in adolescents / Eur J Orthod 18 : 141 ~ 150

[학술지(정기간행물)] - Chan E / 2005 / Physical properties of root cementum: Part 5. Volumetric analysis of root resorption craters after application of light and heavy orthodontic forces / Am J Orthod Dentofacial Orthop 127 : 186 ~ 195

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