Association between soluble forms of the receptor for advanced glycation end products and periodontal disease: a retrospective study

Keun-Suh Kim; Yun Jong Lee; Soyeon Ahn; Yoon-Seok Chang; Yonghoon Choi; Hyo-Jung Lee

doi:10.5125/jkaoms.2021.47.6.445

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자료유형: 학술저널

저자정보: Keun-Suh Kim (Seoul National University Bundang Hospital Seongnam Korea) Yun Jong Lee (Seoul National University Bundang Hospital Seongnam Korea) Soyeon Ahn (Seoul National University Bundang Hospital Seongnam Korea) Yoon-Seok Chang (Seoul National University Bundang Hospital Seongnam Korea) Yonghoon Choi (Seoul National University Bundang Hospital Seongnam Korea) Hyo-Jung Lee (Seoul National University Bundang Hospital Seongnam Korea)

저널정보: 대한구강악안면외과학회 대한구강악안면외과학회지 대한구강악안면외과학회지 제47권 제6호

발행연도: 2021.12

수록면: 445 - 453 (9page)

DOI: 10.5125/jkaoms.2021.47.6.445

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Objectives: Periodontitis is the most common chronic disease that causes tooth loss and is related to systemic diseases such as cardiovascular dis-ease and diabetes. An objective indicator of the current activity of periodontitis is necessary. Soluble forms of the receptor for advanced glycation end products (sRAGE) are markers that reflect the status of inflammatory diseases. In this study, the relationship between sRAGE and periodontitis was analyzed to determine whether it can be used to diagnose the current state of periodontitis. Patients and Methods: Eighty-four patients without any systemic diseases were diagnosed with periodontitis using three classifications of peri-odontitis. Demographics and oral examination data such as plaque index (PI), bleeding on probing (BOP) index, and probing pocket depth (PPD) were analyzed according to each classification. In addition, correlation and partial correlation between sRAGE and the values indicating periodontitis were analyzed. Results: In each classification, the level of sRAGE tended to decrease if periodontitis was present or severe, but this change was not statistically sig-nificant. sRAGE and periodontitis-related variables exhibited a weak correlation, among which the BOP index showed a relatively strong negative cor-relation (ρ=?0.20). Based on this, on analyzing the correlation between the BOP index and sRAGE in the group with more severe periodontitis (PPD≥5 mm group, severe group of AAP/CDC [American Academy of Periodontology/Centers for Disease Control and Prevention], periodontitis group of Lopez), the correlation further increased (ρ=?0.23, ?0.40, ?0.50). Partial correlation analysis of the sRAGE and BOP index showed a stronger negative correlation (ρ=?0.36, ?0.55, ?0.45). Conclusion: sRAGE demonstrated a tendency to decrease upon increased severity of periodontitis according to the classifications used. Above all, the correlation with the BOP index, which reflects the current state of periodontitis, was higher in the group with severe periodontitis. This indicates that the current status of periodontitis can be diagnosed through sRAGE.

#Receptor for advanced glycation end products #Periodontal index #Periodontitis #Bleeding on probing index

참고문헌 (20)

참고문헌 신청

Haidong Wang / 2016 / Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015 / The Lancet 388(10053):1459~1544

Paul I. Eke / 2020 / Recent epidemiologic trends in periodontitis in the USA / Periodontology 2000 82(1):257~267

National Health Insurance Service / 2019 / 2018 National health screening statistical yearbook / National Health Insurance Service

Søren Jepsen / 2017 / Prevention and control of dental caries and periodontal diseases at individual and population level: consensus report of group 3 of joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases / Journal of Clinical Periodontology 44:S85~S93

Harold C. Slavkin / 2000 / Relationship of Dental and Oral Pathology to Systemic Illness / JAMA 284(10):1215

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