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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제46권 제2호
- 발행연도
- 2016.4
- 수록면
- 133 - 138 (6page)
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초록· 키워드
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This study aimed to isolate a lignan-enriched fraction from Schisandra chinensis and improve the dissolution of biologically active lignans via solid dispersion (SD) formulation. Lignan-enriched fraction was obtained from a hexane-soluble extraction, being poorly soluble in water. To improve the dissolution of major lignans from these extracts, SD formulation of an isolated extract was prepared fold in water. SD also lead to the solidification of sticky extract, providing better flowability and ease of handling. Collectively, poloxamwith different hydrophilic polymers. Among the tested carriers, poloxamer 407 was most effective in enhancing the release of active lignans from extract.
Compared to the pure extract, poloxamer 407-based SD significantly increased the dissolution of nine active lignans (schisandrol A, gomisin J, schisandrol B, tigloylgomisin H, angeloylgomisin H, schisandrin A, schisandrin B, gomisin N, schisandrin C) by 1.6- to 300-er 407-based SD formulation appeared to be effective in enhancing the dissolution of the active lignans from S. Chinensis.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Ahuja N. / 2007 / Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers / Eur J Pharm Biopharm 65:26~38
Attwood D. / 1985 / The micellar properties of the poly(oxyethylene)-poly(oxypropylene)copolymer Pluronic F127 in water and electrolyte solution / Int J Pharm 26:25~33
Chutimaworapan S. / 2000 / Effect of water-soluble carriers on dissolution characteristics of nifedipine solid dispersions / Drug Dev Ind Pharm 26:1141~1150
Dimitrova E. / 2000 / Development of model aqueous ophthalmic solution of indomethacin / Drug Dev Ind Pharm 26:1297~1301
Dumortier G. / 2006 / A review of poloxamer 407 pharmaceutical and pharmacological characteristics / Pharm Res 23:2709~2728
Attwood D. / 1985 / The micellar properties of the poly(oxyethylene)-poly(oxypropylene)copolymer Pluronic F127 in water and electrolyte solution / Int J Pharm 26:25~33
Chutimaworapan S. / 2000 / Effect of water-soluble carriers on dissolution characteristics of nifedipine solid dispersions / Drug Dev Ind Pharm 26:1141~1150
Dimitrova E. / 2000 / Development of model aqueous ophthalmic solution of indomethacin / Drug Dev Ind Pharm 26:1297~1301
Dumortier G. / 2006 / A review of poloxamer 407 pharmaceutical and pharmacological characteristics / Pharm Res 23:2709~2728
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