지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Growth hormone (GH) is widely used to treat growth disorders in patients with either GH deficiency (GHD) or non-GHD. However, the effects of GH therapy are inconsistent. The aim of this study was to investigate the effect of growth hormone therapy on height in children and adolescents in South Korea. A retrospective clinical analysis was conducted using the electronic medical records of the subjects who started GH therapy between January 2013 and December 2014 at a teaching hospital located in Seoul, Korea. In order to evaluate the effect of GH therapy, the auxological parameters such as height, height standard deviation scores (SDS), and height velocity was analyzed according to the duration of treatment and baseline height SDS. A total of 428 subjects were analyzed. GH therapy improved height SDS in the subjects treated for no more than 1 year as well as more than 1 year (0.27 vs. 0.68, p=0.006). Height SDS gain was significantly greater in the subjects with lower height SDS than the subjects with higher one at baseline (1.22 for SDS < -2 vs. $-2{\leq}SDS$ < 0, p < 0.001; 1.23 for $-2{\leq}SDS$ < 0 vs. $0{\leq}SDS$, p < 0.001). Negative correlations were found between increase in height SDS after treatment and both baseline age and height SDS (r=-0.33 for age; r=-0.38 for height SDS, both p < 0.001).
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Raven, M. S / 1958 / Treatment of a pituitary dwarf with human growth hormone / J. Clin. Endocrinol. Metab 18:901
Croes, E. A / 2002 / Creutzfeldt-Jakob disease 38 years after diagnostic use of human growth hormone / J. Neurol. Neurosurg. Psychiatry 72:792
Richmond, E / 2010 / Current indications for growth hormone therapy for children and adolescents / Endocr. Dev 18:92
이기형 / 2008 / 약물요법/저신장 소아의 성장호르몬 치료 / 대한의사협회지 51(9):849~855
Woelfle, J / 2003 / Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation / J. Biol. Chem 278:51261
Croes, E. A / 2002 / Creutzfeldt-Jakob disease 38 years after diagnostic use of human growth hormone / J. Neurol. Neurosurg. Psychiatry 72:792
Richmond, E / 2010 / Current indications for growth hormone therapy for children and adolescents / Endocr. Dev 18:92
이기형 / 2008 / 약물요법/저신장 소아의 성장호르몬 치료 / 대한의사협회지 51(9):849~855
Woelfle, J / 2003 / Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation / J. Biol. Chem 278:51261
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