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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.8
- 수록면
- 625 - 630 (6page)
- DOI
- molcells.2016.0150
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초록· 키워드
오류제보하기
The RNA-binding protein Rbfox3 is a well-known splicing regulator that is used as a marker for post-mitotic neurons in various vertebrate species. Although recent studies indicate a variable expression of Rbfox3 in non-neuronal tissues, including lung tissue, its cellular function in lung cancer remains largely unknown. Here, we report that the number of RBFOX3-positive cells in tumorous lung tissue is lower than that in normal lung tissue. As the transforming growth factor-? (TGF-?) signaling pathway is important in cancer progression, we investigated its role in RBFOX3 expression in A549 lung adenocarcinoma cells. TGF-?1 treatment inhibited RBFOX3 expression at the transcriptional level. Further, RBFOX3 depletion led to a change in the expression levels of a subset of proteins related to epithelial-mesenchymal transition (EMT), such as E-cadherin and Claudin-1, during TGF-?1-induced EMT. In immunofluorescence microscopic analysis, mesenchymal morphology was more prominent in RBFOX3-depleted cells than in control cells. These findings show that TGF-?-induced RBFOX3 inhibition plays an important role in EMT and propose a novel role for RBFOX3 in cancer progression.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Amin, N. / 2016 / Genetic variants in RBFOX3 are associated with sleep latency / Eur J Hum Genet
Arya, A. D. / 2014 / RBFOX2 protein domains and cellular activities / Biochem. Soc. Trans 42:1180~1183
Braeutigam, C. / 2014 / The RNA-binding protein Rbfox2 : an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion / Oncogene 33:1082~1092
Carreira-Rosario, A. / 2016 / Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation / Dev. Cell 36:562~571
de Caestecker, M. P. / 2000 / Role of transforming growth factor-beta signaling in cancer / J. Natl. Cancer Inst 92:1388~1402
Arya, A. D. / 2014 / RBFOX2 protein domains and cellular activities / Biochem. Soc. Trans 42:1180~1183
Braeutigam, C. / 2014 / The RNA-binding protein Rbfox2 : an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion / Oncogene 33:1082~1092
Carreira-Rosario, A. / 2016 / Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation / Dev. Cell 36:562~571
de Caestecker, M. P. / 2000 / Role of transforming growth factor-beta signaling in cancer / J. Natl. Cancer Inst 92:1388~1402
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