지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.4
- 수록면
- 170 - 185 (16page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Particulate matter 2.5 (PM2.5) exposure can promote epithelial- mesenchymal transition (EMT) in human retinal pigment epithelial (RPE) cells. The flowers of Tagetes erecta Linn, commonly known as marigold, are rich in diverse flavonoids and carotenoids and play a significant role in preventing cellular damage induced by oxidative stress, but the role of their extracts in RPE cells has not been reported. This study aimed to evaluate the influence of an ethanol extract of T. erecta Linn flower (TE) on PM2.5-induced EMT processes in RPE ARPE-19 cells.
MATERIALS/METHODS: To investigate the protective effect of TE against ARPE-19 cell damage following PM2.5 treatment, cells were exposed to TE for 1 h before exposure to PM2.5 for 24 h. We investigated whether the efficacy of TE on suppressing PM2.5-induced EMT was related to antioxidant activity and the effect on the expression changes of factors involved in EMT regulation. Additionally, we further explored the role of intracellular signaling pathways associated with EMT inhibition.
RESULTS: TE significantly blocked PM2.5-induced cytotoxicity while effectively preventing mitochondrial dysfunction, increased reactive oxygen species (ROS) generation, and mitochondrial membrane potential disruption. TE inhibited PM2.5-induced EMT and inflammatory response by suppressing the ROS-mediated transforming growth factor-β/ suppressor of mothers against decapentaplegic/mitogen-activated protein kinases signaling pathway.
CONCLUSION: Our results suggest that marigold extract is a highly effective in protection against PM2.5-induced eye damage.
MATERIALS/METHODS: To investigate the protective effect of TE against ARPE-19 cell damage following PM2.5 treatment, cells were exposed to TE for 1 h before exposure to PM2.5 for 24 h. We investigated whether the efficacy of TE on suppressing PM2.5-induced EMT was related to antioxidant activity and the effect on the expression changes of factors involved in EMT regulation. Additionally, we further explored the role of intracellular signaling pathways associated with EMT inhibition.
RESULTS: TE significantly blocked PM2.5-induced cytotoxicity while effectively preventing mitochondrial dysfunction, increased reactive oxygen species (ROS) generation, and mitochondrial membrane potential disruption. TE inhibited PM2.5-induced EMT and inflammatory response by suppressing the ROS-mediated transforming growth factor-β/ suppressor of mothers against decapentaplegic/mitogen-activated protein kinases signaling pathway.
CONCLUSION: Our results suggest that marigold extract is a highly effective in protection against PM2.5-induced eye damage.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Tagetes erecta Linn flower extract inhibits particulate matter 2.5-promoted epithelial-mesenchymal transition by attenuating reactive oxygen species generation in human retinal pigment epithelial ARPE-19 cells
Nutrition Research and Practice
2025 .04
-
기상 조건이 서울의 PM 2.5와 PM 10에 미치는 영향
한국기후변화학회지
2020 .10
-
Unexpected electromagnetic behavior of van der Waals transition metal chalcogenide TaCoxTe₂
한국자기학회 학술연구발표회 논문개요집
2022 .05
-
눈에 대한 미세먼지의 독성 평가를 위한 쥐 각막 상피 세포의 적용
생명과학회지
2022 .09
-
Schisandrae Fructus ethanol extract attenuates particulate matter 2.5-induced inflammatory and oxidative responses by blocking the activation of the ROS-dependent NF-κB signaling pathway
Nutrition Research and Practice
2021 .12
-
Schisandrae Fructus ethanol extract attenuates particulate matter 2.5-induced inflammatory and oxidative responses by blocking the activation of the ROS-dependent NF-κB signaling pathway
Nutrition Research and Practice
2021 .12
-
Composition Characteristics of PM10 and PM2.5 Fine Particulate Matters during Haze Days in 2014 at Background Area of Korea
한국분석과학회 학술대회
2015 .11
-
Particulate matters CRMs for the quality control of analytical results and basic researches
한국분석과학회 학술대회
2021 .05
-
초등학교 실내외 미세먼지 농도 비교 연구
대한원격탐사학회지
2020 .01
-
Effects of the Particulate Matter2.5 (PM2.5) on Lipoprotein Metabolism, Uptake and Degradation, and Embryo Toxicity
Molecules and Cells
2015 .12
-
해당화 추출물의 미세먼지로 유도된 피부 손상 및 노화 억제 효과
한국해양바이오학회지
2024 .12
-
Activation of Nrf2/HO-1 antioxidant signaling correlates with the preventive effect of loganin on oxidative injury in ARPE-19 human retinal pigment epithelial cells
Genes & Genomics
2023 .03
-
Analysis of seasonal variations of particulate matter-carrying materials
한국분석과학회 학술대회
2021 .05
-
실내 외 농도 비(I/O ratio)에 기반한 주변환경과 실내 미세먼지 농도분포 특성: 선행연구 리뷰와 여름철 부산과 평택 초등학교에서의 측정 결과를 중심으로
대한원격탐사학회지
2020 .01
-
광주지역 초미세먼지(PM 2.5)의 특성에 관한 연구
대한지질학회 학술대회
2015 .10
-
nthocyanins Inhibits Oxidative Injury in Human Retinal Pigment Epithelial ARPE-19 Cells via Activating Heme Oxygenase-1
Journal of Microbiology and Biotechnology
2024 .03
-
Role of Particulate Matter in Skin Inflammation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .06
-
인공지능을 이용한 수도권 학교 미세먼지 취약성 평가: Part I - 미세먼지 예측 모델링
대한원격탐사학회지
2021 .12
-
라이다 데이터를 이용한 PM10, PM2.5 질량소산효율 특성 연구
대한원격탐사학회지
2021 .12
-
Particulate matter-induced gene expression patterns in human-derived cells based on 11 public gene expression datasets
Genes & Genomics
2024 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0