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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 893 - 899 (7page)
- DOI
- 10.14348/molcells.2021.0159
이용수
초록· 키워드
오류제보하기
BLT2 is a low-affinity receptor for leukotriene B4, a potent lipid mediator of inflammation generated from arachidonic acid via the 5-lipoxygenase pathway. The aim of this study was to investigate whether BLT2 plays any role in sepsis, a systemic inflammatory response syndrome caused by infection. A murine model of cecal ligation and puncture (CLP)-induced sepsis was used to evaluate the role of BLT2 in septic inflammation. In the present study, we observed that the levels of ligands for BLT2 (LTB4 [leukotriene B4] and 12(S)-HETE [12(S)-hydroxyeicosatetraenoic acid]) were significantly increased in the peritoneal lavage fluid and serum from mice with CLP-induced sepsis. We also observed that the levels of BLT2 as well as 5-LO and 12-LO, which are synthesizing enzymes for LTB4 and 12(S)-HETE, were significantly increased in lung and liver tissues in the CLP mouse model. Blockade of BLT2 markedly suppressed the production of sepsis-associated cytokines (IL-6 [interleukin-6], TNF-α [tumor necrosis factor alpha], and IL-1β [interleukin-1β] as well as IL-17 [interleukin-17]) and alleviated lung inflammation in the CLP group. Taken together, our results suggest that BLT2 cascade contributes to lung inflammation in CLP-induced sepsis by mediating the production of inflammatory cytokines. These findings suggest that BLT2 may be a potential therapeutic target for sepsis patients.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Benjamim, C. F. / 2005 / Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis / J. Immunol 174:1616~1620
Bitto, A. / 2012 / Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis / Crit. Care 16:R32
Chaudhry, H. / 2013 / Role of cytokines as a double-edged sword in sepsis / In Vivo 27:669~684
조동형 / 2020 / Mitophagy and Innate Immunity in Infection / Molecules and Cells 43(1):10~22
최은정 / 2020 / Allithiamine Exerts Therapeutic Effects on Sepsis by Modulating Metabolic Flux during Dendritic Cell Activation / Molecules and Cells 43(11):964~973
Bitto, A. / 2012 / Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis / Crit. Care 16:R32
Chaudhry, H. / 2013 / Role of cytokines as a double-edged sword in sepsis / In Vivo 27:669~684
조동형 / 2020 / Mitophagy and Innate Immunity in Infection / Molecules and Cells 43(1):10~22
최은정 / 2020 / Allithiamine Exerts Therapeutic Effects on Sepsis by Modulating Metabolic Flux during Dendritic Cell Activation / Molecules and Cells 43(11):964~973
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