지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 765 - 772 (8page)
- DOI
- 10.14348/molcells.2015.0062
이용수
초록· 키워드
오류제보하기
Saussurea lappa has been reported to possess anti-atopic properties. In this study, we have confirmed the S. lappa’s anti-atopic properties in Nc/Nga mice and investigated the candidate gene related with its properties using microarray.
We determined the target gene using real time PCR in in vitro experiment. S. lappa showed the significant reduction in atoptic dermatitis (AD) score and immunoglobulin E compared with the AD induced Nc/Nga mice. In the results of microarray using back skin obtained from animals, we found that S. lappa’s properties are closely associated with cytokine-cytokine receptor interaction and the JAKSTAT signaling pathway. Consistent with the microarray data, real-time RT-PCR confirmed these modulation at the mRNA level in skin tissues from S. lappa-treated mice.
Among these genes, PI3Kca and IL20Rβ were significantly downregulated by S. lappa treatment in Nc/Nga mouse model. In in vitro experiment using HaCaT cells, we found that the S. lappa components, including alantolactone, caryophyllene, costic acid, costunolide and dehydrocostus lactone significantly decreased the expression of PI3Kca but not IL20Rβ in vitro. Therefore, our study suggests that PI3Kca-related signaling is closely related with the protective effects of S. lappa against the development of atopic-dermatitis.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Bader, A. G. / 2005 / Oncogenic PI3K deregulates transcription and translation / Nat. Rev. Cancer 5:921~929
Barnes, K. C. / 2010 / An update on the genetics of atopic dermatitis : scratching the surface in 2009 / J. Allergy Clin. Immunol 125:16~29
Borden, E. C. / 2007 / Interferons at age 50 : past, current and future impact on biomedicine / Nat. Rev. Drug Discov 6:975~990
Burchill, M. A. / 2007 / Interleukin-2 receptor signaling in regulatory T cell development and homeostasis / Immunol. Lett 114:1~8
Byambaragchaa, M. / 2014 / Anticancer potential of an ethanol extract of saussurea involucrata against hepatic cancer cells in vitro / Asian Pac. J. Cancer Prev 15:7527~7532
Barnes, K. C. / 2010 / An update on the genetics of atopic dermatitis : scratching the surface in 2009 / J. Allergy Clin. Immunol 125:16~29
Borden, E. C. / 2007 / Interferons at age 50 : past, current and future impact on biomedicine / Nat. Rev. Drug Discov 6:975~990
Burchill, M. A. / 2007 / Interleukin-2 receptor signaling in regulatory T cell development and homeostasis / Immunol. Lett 114:1~8
Byambaragchaa, M. / 2014 / Anticancer potential of an ethanol extract of saussurea involucrata against hepatic cancer cells in vitro / Asian Pac. J. Cancer Prev 15:7527~7532
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