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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 441 - 447 (7page)
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Background Respiratory diseases in pigs are the main health concerns for swine producers. Similar to the diseases in human and other animals, respiratory diseases are primary related to morbidity and are the result of infection with bacteria, viruses, or both. B. bronchiseptica causes serious respiratory diseases in the swine airway track. However, the B. bronchisepticaspecific bacteriophage has diverse advantages such as decreasing antibiotic overuse and possible therapeutic potential against bacteria. Objective The objects of this study were to investigate the therapeutic effect of specific B. bronchiseptica bacteriophages and to identify genes related to bacteriophage signaling utilizing RNA microarrays in swine nasal turbinate cells. Methods Bor-BRP-1 phages were applied 24 h prior to B.bronchiseptica infection (1 × 107 cfu/ml) at several concentrations of bacterial infection. Cells were incubated to detect cytokines and 24 h to detect mucin production. And real-time quantitative PCR was performed to examine related genes expression. To determine the change of total gene expression based on B.bronchiseptica and Bor-BRP-1 treatment, we performed RNA sequencing experiments. Results The results showed that B. bronchiseptica induced increased expression of several inflammatory genes such as IL-1β, IL-6, and Muc1 in a dose-dependent manner. However, Bor-BRP-1 induced reduction of gene expression compared to the B. bronchiseptica induction group. In addition, microarrays detected Bor-BRP-1-altered inflammatory gene expression against B. bronchiseptica, reducing B. bronchiseptica-induced airway inflammation in swine epithelial cells. Conclusion These results suggest that the specific bacteriophage has a therapeutic potential to defend against B. bronchiseptica infection by altering inflammatory gene expression profiles.
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참고문헌 (28)
참고문헌 신청
Biswas B / 2002 / Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium / Infect Immun 70:204~210
Brockmeier SL / 2004 / Prior infection with Bordetella bronchiseptica increases nasal colonization by Haemophilus parasuis in swine / Vet Microbiol 99:75~78
Brockmeier SL / 2002 / Role of the dermonecrotic toxin of Bordetella bronchiseptica in the pathogenesis of respiratory disease in swine / Infect Immun 70:481~490
Chen Y / 2019 / Characterisation of a newly detected bacteriophage infecting Bordetella bronchiseptica in swine / Arch Virol 164:33~40
Dayao DA / 2014 / Antimicrobial resistance in bacteria associated with porcine respiratory disease in Australia / Vet Microbiol 171:232~235
Brockmeier SL / 2004 / Prior infection with Bordetella bronchiseptica increases nasal colonization by Haemophilus parasuis in swine / Vet Microbiol 99:75~78
Brockmeier SL / 2002 / Role of the dermonecrotic toxin of Bordetella bronchiseptica in the pathogenesis of respiratory disease in swine / Infect Immun 70:481~490
Chen Y / 2019 / Characterisation of a newly detected bacteriophage infecting Bordetella bronchiseptica in swine / Arch Virol 164:33~40
Dayao DA / 2014 / Antimicrobial resistance in bacteria associated with porcine respiratory disease in Australia / Vet Microbiol 171:232~235
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