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논문 기본 정보

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학술저널
저자정보
Mostafa Rahvar (Iran University of Medical Sciences) Gholamreza Ahmadi Lakalayeh (Tehran University of Medical Sciences (TUMS)) Niloofar Nazeri (Tehran University of Medical Sciences (TUMS)) Bahereh T. Marouf (Urmia University) Mahdieh Shirzad (University of Tehran) Azar Najafi T. Shabankareh (Tehran University of Medical Sciences (TUMS)) Hossein Ghanbari (Tehran University of Medical Sciences (TUMS))
저널정보
대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.11 No.4
발행연도
2021.12
수록면
393 - 406 (14page)
DOI
https://doi.org/10.1007/s13534-021-00205-9

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The efficacy of an implant is highly depends on its coating characteristics mainly determined by polymer properties and coating technique. Electro-spraying is an inexpensive and versatile coating technique with various advantages for biomedical application. In this study, the efficacy of electro-sprayed (ES) poly lactic acid (PLA)-dexamethasone (DEX) coatings for medical implants was evaluated and compared with spin-coated samples as control. Structural properties of coatings were investigated using X-ray diffraction (XRD) and differential scanning calorimetry (DSC). Confocal and scanning electron microscopy (SEM), contact angle measurement and nanoindentation tests were used to study surface properties. Coating degradation rate and drug release profile were studied for 40 days. Cell viability experiments were also performed on human endothelial (HUVEC) and smooth muscle cells (HUASMC) using MTT assay and SEM. XRD and DSC analysis showed electro-spraying significantly reduce PLA and DEX crystallinity. Surface studies showed ES coatings has significantly higher hydrophobicity and roughness with microbead-nanofiber morphology vs. micro-nanoporous structure of spin-coated samples. Initial burst release of DEX was 22% and 10% after 6 h and total release was 71% and 46% after 40 days for ES and spin-coated samples, respectively. HUVEC viability of ES samples was higher than spin-coated ones after 1 and 4 days. However, dexamethasone release profile reduced HUASMC proliferation in ES PLA-DEX samples in comparison to spin-coated after 1 and 3 days. In conclusion, in vitro results showed potential of ES PLA-DEX as a biocompatible and efficient anti-inflammatory coating with suitable drug release profile for future applications such as coronary drug eluting stents.
#Implants Nano topography Drug release Wettability Biodegradation

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참고문헌 (79)

참고문헌 신청
Alizadeh-Osgouei M / 2019 / A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications / Bioactive Mater 4:22~36 google schola Prakasam M / 2017 / Biodegradable materials and metallic implants—a review / J Funct Biomater 8(4):44 google schola Rousset F / 2019 / Poly-lactic acid-based biopolymer formulations are safe for sustained intratympanic dexamethasone delivery / Otol Neurotol 40(7):e739~e746 google schola Tanetsugu Y / 2017 / Development of a sustainable release system for a ranibizumab biosimilar using poly(lactic-co-glycolic acid)biodegradable polymer-based microparticles as a platform / Biol Pharm Bull 40(2):145~150 google schola Ahmadi Lakalayeh G / 2018 / Comparative study of different polymeric coatings for the next-generation magnesiumbased biodegradable stents / Artif Cells Nanomed Biotechnol 46(7):1380~1389 google schola

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