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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제48권 제3호
- 발행연도
- 2018.5
- 수록면
- 381 - 391 (11page)
- DOI
- 10.1007/s40005-017-0334-8
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초록· 키워드
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Tri-block poly(lactide)?poly(ethylene glycol)? poly(lactide) (PLA?PEG?PLA) copolymers were synthesized and self-assembled into micelles in aqueous solution by double emulsion and nanoprecipitation methods.
These micelles were loaded by atorvastatin and lisinopril as hydrophobic and hydrophilic model drugs, respectively.
The resulting nanostructures were characterized by various techniques. Atomic force microscopy images disclosed that the micelles have spherical structure with the average size of 100 nm. The micelles exhibited high encapsulation efficiency of about 48 ± 0.13% and 84 ± 0.13 for atorvastatin and lisinopril, respectively. Fourier transform infrared spectroscopy and differential scanning calorimetry confirmed that strong interaction between atorvastatin and copolymer was the major driving force behind drug loading which subsequently lead to more sustained release behavior of corresponding micelles. Whereas, in case of lisinopril there was no evidence for strong interaction between drug and copolymer. The surface adsorption was the main parameter for drug loading which in turn caused the drug to be quick released. Overall, the results indicated that PLA? PEG?PLA micelles can be considered as a promising carrier for both hydrophilic and hydrophobic drugs with different release characteristics.
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참고문헌 (22)
참고문헌 신청
Asadi H / 2011 / Preparation and characterization of tri-block poly(lactide)-poly(ethylene glycol)-poly(lactide) nanogels for controlled release of naltrexone / Int J Pharm 416:356~364
Danafar H / 2014 / Biodegradable m-PEG/PCL core-shell micelles: preparation and characterization as a sustained release formulation for curcumin / Adv Pharm Bull 4:501~510
Danafar H / 2014 / PLAPEG-PLA copolymer-based polymersomes as nanocarriers for delivery of hydrophilic and hydrophobic drugs: preparation and evaluation with atorvastatin and lisinopril / Drug Dev Ind Pharm 40:1411~1420
Danafar H / 2015 / Drugconjugated PLA-PEG-PLA copolymers: a novel approach for controlled delivery of hydrophilic drugs by micelle formation / Pharm Dev Technol
Danafar H / 2016 / Study of copolymer composition on drug loading efficiency of enalapril in polymersomes and cytotoxicity of drug loaded nanoparticles / Drug Res 66:495~504
Danafar H / 2014 / Biodegradable m-PEG/PCL core-shell micelles: preparation and characterization as a sustained release formulation for curcumin / Adv Pharm Bull 4:501~510
Danafar H / 2014 / PLAPEG-PLA copolymer-based polymersomes as nanocarriers for delivery of hydrophilic and hydrophobic drugs: preparation and evaluation with atorvastatin and lisinopril / Drug Dev Ind Pharm 40:1411~1420
Danafar H / 2015 / Drugconjugated PLA-PEG-PLA copolymers: a novel approach for controlled delivery of hydrophilic drugs by micelle formation / Pharm Dev Technol
Danafar H / 2016 / Study of copolymer composition on drug loading efficiency of enalapril in polymersomes and cytotoxicity of drug loaded nanoparticles / Drug Res 66:495~504
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