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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 391 - 408 (18page)
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In our previous studies, wheat-extract powder and/or wheat-bran extract powder, processed through centrifugation, showed efficacy in rodent models for Alzheimer’s disease (AD) and myocardial infarction (MI), and improved memory in elderly who complained of memory impairment. However, the development of a new processing method that does not require a centrifugation step is necessary for the efficient and inexpensive processing of functional foods. In this study, we prepared whole-wheat extract powder (WWE) from three Korean wheat varieties: Anbaek, Anzunbaengi, and Goso, by grinding, extraction, and drying. Initially, all three WWEs were tested in a rat MI model and Anbaek WWE was chosen as the final candidate as it significantly reduced myocardial injury even at the lowest dose of 31 mg/kg per day. Additionally, Anbaek wheat flour contained the highest quantity of water-extractable arabinoxylan (WE-AX), an active ingredient, compared to the other varieties tested. Anbaek WWE was then tested in a mouse AD model wherein WWE administration showed maximum memory improvement at a dosage of 125 mg/kg. One underlying mechanism by which Anbaek WWE improved memory was by enhancing neurotransmission at glutamatergic synapses. Based on these results, we recommend Anbaek WWE as a potential candidate to be developed as a functional food to prevent AD and MI at a dosage of 1 g/day per person, which was calculated using a standard conversion factor.
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참고문헌 (47)
참고문헌 신청
Bassani, S. / 2013 / The neurobiology of X-linked intellectual disability / Prog Clin Neurosci 19:541~552
Buccafusco, J. J. / 2009 / Methods of Behavior Analysis in Neuroscience / CRC Press/Taylor & Francis
Chen, Y. / 2019 / Synaptic dysfunction in Alzheimer’s disease : Mechanisms and therapeutic strategies / Pharmacol Ther 195:186~198
Choi, E. K. / 2018 / Wheat bran improves cognition in older adults with memory impairment: A randomized controlled trial / Int J Pharmacol 14:922~928
Coley, A. A. / 2018 / PSD95 : A synaptic protein implicated in schizophrenia or autism? / Prog Neuropsychopharmacol Biol Psychiatry 82:187~194
Buccafusco, J. J. / 2009 / Methods of Behavior Analysis in Neuroscience / CRC Press/Taylor & Francis
Chen, Y. / 2019 / Synaptic dysfunction in Alzheimer’s disease : Mechanisms and therapeutic strategies / Pharmacol Ther 195:186~198
Choi, E. K. / 2018 / Wheat bran improves cognition in older adults with memory impairment: A randomized controlled trial / Int J Pharmacol 14:922~928
Coley, A. A. / 2018 / PSD95 : A synaptic protein implicated in schizophrenia or autism? / Prog Neuropsychopharmacol Biol Psychiatry 82:187~194
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