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Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
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논문 기본 정보

Type
Academic journal
Author
Bang Kyuhoon (강동경희대학교병원) Jun Ji Eun (강동경희대학교병원) In-Kyung Jeong (강동경희대학교병원) Kyu Jeung Ahn (경희대학교) CHUNG HO YEON (강동경희대학교병원) You-Cheol Hwang (강동경희대학교병원)
Journal
대한당뇨병학회 Diabetes and Metabolism Journal Diabetes and Metabolism Journal Vol.45 No.6 KCI Accredited Journals
Published
2021.11
Pages
890 - 898 (9page)
DOI
10.4093/dmj.2020.0208

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Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
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Background: Fatty liver and/or increased liver enzyme values have been reported to be associated with incident diabetes. We sought to determine whether increased visit-to-visit liver enzyme variability is associated with incident diabetes.Methods: Study participants were recruited from the Korean Genome and Epidemiologic Study (KoGES). A total of 4,151 people aged 40 to 69 years was recruited and tested every 2 years for up to 12 years. Visit-to-visit aspartate aminotransferase (AST) and alanine aminotransferase (ALT) variability was evaluated in first the 6-year period through the use of various variability measurements: standard deviation (SD), average successive variability, coefficient of variation (CV), and variation independent of mean (VIM). Oral glucose tolerance test was performed at every visit.Results: During the 6-year follow?up appointments, 13.0% (538/4,151) of people developed incident diabetes. Visit-to-visit AST variability was associated with an increased risk of diabetes independent of conventional risk factors for diabetes (hazard ratio per 1-SD increment [95% confidence interval]: 1.06 [1.00 to 1.11], 1.12 [1.04 to 1.21], and 1.13 [1.04 to 1.22] for SD, CV, and VIM, respectively; all P<0.05); however, no such associations were observed in the visit-to-visit ALT variability. According to alcohol consumption status, both AST and ALT variability were independent predictors for incident diabetes in subjects with heavy alcohol consumption; however, neither AST nor ALT variability was associated with diabetes risk in subjects who did not drink alcohol heavily.Conclusion: Visit-to-visit liver enzyme variability is an independent predictor of incident diabetes. Such association was more evident in those who consumed significant amounts of alcohol.
#Alanine transaminase #Aspartate aminotransferases #Biological variation #Diabetes mellitus #type 2 #Korea #Cohort studies

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References (26)

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이용호 / 2019 / Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis / Diabetes and Metabolism Journal 43(1):31~45 dbpia Targher G / 2018 / Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus / Nat Rev Endocrinol 14:99~114 google schola Valenti L / 2016 / Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes? / Liver Int 36:1563~1579 google schola Mantovani A / 2018 / Nonalcoholic fatty liver disease and risk of incident type 2 diabetes : a metaanalysis / Diabetes Care 41:372~382 google schola Bangalore S / 2018 / Body weight variability and cardiovascular outcomes in patients with type 2 diabetes mellitus / Circ Cardiovasc Qual Outcomes 11:e004724 google schola

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