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Effects of Cardiovascular Risk Factor Variability on Health Outcomes
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논문 기본 정보

Type
Academic journal
Author
Lee Seung Hwan (가톨릭대학교) Kim Mee Kyoung (가톨릭대학교) RHEE EUN JUNG (성균관대학교)
Journal
Korean Endocrine Society Endocrinology and Metabolism Endocrinology and Metabolism Vol.35 No.2 KCI Accredited Journals
Published
2020.1
Pages
217 - 226 (10page)

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Effects of Cardiovascular Risk Factor Variability on Health Outcomes
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Abstract· Keywords

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Innumerable studies have suggested “the lower, the better” for cardiovascular risk factors, such as body weight, lipid profile, bloodpressure, and blood glucose, in terms of health outcomes. However, excessively low levels of these parameters cause health problems, as seen in cachexia, hypoglycemia, and hypotension. Body weight fluctuation is related to mortality, diabetes, obesity, cardiovascular disease, and cancer, although contradictory findings have been reported. High lipid variability is associated with increasedmortality and elevated risks of cardiovascular disease, diabetes, end-stage renal disease, and dementia. High blood pressure variability is associated with increased mortality, myocardial infarction, hospitalization, and dementia, which may be caused by hypotension. Furthermore, high glucose variability, which can be measured by continuous glucose monitoring systems or self-monitoring ofblood glucose levels, is associated with increased mortality, microvascular and macrovascular complications of diabetes, and hypoglycemic events, leading to hospitalization. Variability in metabolic parameters could be affected by medications, such as statins, antihypertensives, and hypoglycemic agents, and changes in lifestyle patterns. However, other mechanisms modify the relationshipsbetween biological variability and various health outcomes. In this study, we review recent evidence regarding the role of variabilityin metabolic parameters and discuss the clinical implications of these findings.
#Variability #Glucose #Blood pressure #Body weight #Lipids #Mortality #Cardiovascular diseases

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References (82)

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Grundy SM / 2019 / 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol : a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines / Circulation 139:e1082~143 google schola Mach F / 2020 / 2019 ESC/EAS guidelines for the management of dyslipidaemias : lipid modification to reduce cardiovascular risk / Eur Heart J 41:111~188 google schola Sabatine MS / 2017 / Evolocumab and clinical outcomes in patients with cardiovascular disease / N Engl J Med 376:1713~1722 google schola SPRINT Research Group / 2015 / A randomized trial of intensive versus standard blood-pressure control / N Engl J Med 373:2103~2116 google schola 박성하 / 2019 / Ideal Target Blood Pressure in Hypertension / Korean Circulation Journal 49(11):1002~1009 dbpia

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