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논문 기본 정보

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학술저널
저자정보
Chen Cai-Ling (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong) Wang Yu-Ting (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong) Yao Yin (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong) Pan Li (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong) Guo Bei (Department of Otolaryngology-Head and Neck Surgery Wuhan Central Hospital Tongji Medical College Hu) Zhu Ke-Zhang (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong) Ma Jin (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong) Wang Nan (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong) Li Xue-Li (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong) Deng Yi-Ke (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong) Liu Zheng (Department of Otolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.6
발행연도
2021.11
수록면
863 - 881 (19page)
DOI
10.4168/aair.2021.13.6.863

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Purpose: The pathogenic mechanisms of antrochoanal polyps (ACPs) remain largely unknown. This study aimed to characterize inflammatory patterns and tissue remodeling features in ACPs. Methods: Inflammatory cell infiltration and tissue edema severity as well as fibrin deposition in ACPs and bilateral eosinophilic and noneosinophilic nasal polyps (NPs) were studied with immunohistochemical and immunofluorescence staining. Cytokine levels in sinonasal tissues were detected with the Bio-Plex assay. The expression of coagulation and fibrinolytic markers was measured using reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assays. Results: Compared to control tissues and bilateral eosinophilic and noneosinophilic NPs, ACPs had higher levels of neutrophil infiltration and expression of myeloperoxidase (MPO), interleukin (IL)-8 and interferon (IFN)-γ. In total, 94.4% of ACPs demonstrated an eosinophil cationic protein/MPO ratio of < 1, compared to 79.0% of noneosinophilic and 26% of eosinophilic NPs. Principle component and multiple correspondence analyses revealed a neutrophilic and type 1 inflammation pattern in ACPs. Compared to control tissues, edema scores and fibrin deposition were increased, whereas d-dimer and tissue plasminogen activator (tPA) levels were decreased in ACPs and bilateral NPs, with more prominent changes in ACPs even than in eosinophilic NPs. The tPA levels were negatively correlated with IFN-γ, IL-8, and MPO levels in ACPs. Neutrophils were the major cellular source of IFN-γ in ACPs, and the number of IFN-γ+ neutrophils was elevated in ACPs than in control tissues and bilateral eosinophilic and noneosinophilic NPs. Conclusions: ACPs are characterized by the neutrophilic and type 1 inflammation endotype. Neutrophil-derived IFN-γ is associated with reduced tPA production in ACPs.
#Nasal polyps #tissue plasminogen activator #interferon #neutrophils #inflammation #edema

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참고문헌 (48)

참고문헌 신청
Hong SK / 2001 / Endoscopic removal of the antral portion of antrochoanal polyp by powered instrumentation / Laryngoscope 111:1774~1778 google schola Huseyin Yaman, MD / 2010 / Evaluation and Management of Antrochoanal Polyps / Clinical and Experimental Otorhinolaryngology 3(2):110~114 google schola El-Sharkawy AA / 2013 / Endoscopic management of paediatric antrochoanal polyp : our experience / Acta Otorhinolaryngol Ital 33:107~111 google schola Kizil Y / 2014 / Analysis of choanal polyps / J Craniofac Surg 25:1082~1084 google schola Ozdek A / 2002 / Antrochoanal polyps in children / Int J Pediatr Otorhinolaryngol 65:213~218 google schola

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