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논문 기본 정보

자료유형
학술저널
저자정보
노경백 (바이오스펙트럼 생명과학연구소) 신영희 (바이오스펙트럼 생명과학연구소) 박덕훈 (바이오스펙트럼(주)) 정은선 (바이오스펙트럼 생명과학연구소)
저널정보
대한미용학회 대한미용학회지 대한미용학회지 제17권 제4호
발행연도
2021.12
수록면
393 - 399 (7page)
DOI
10.15810/jic.2021.17.4.006

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In the treatment of chronic inflammatory skin diseases, topical steroids are known to show strong efficacy in relieving inflammation. Nevertheless, because its use in treatment is limited due to the side effects of long-term use, development of a therapeutic agent using natural products is necessary. Studies on various natural products with anti inflammatory effects are currently being conducted, however few studies verifying the anti-inflammatory effect of natural products through direct comparison with steroids have been reported. In this study, the anti-inflammatory effect of BSASM, a complex of seven natural products, and hydrocortisone, a topical steroid, were directly compared, and the effectiveness of BSASM as an anti-inflammatory agent was evaluated. Compared with hydrocortisone (topical steroids), BSASM had a similar inhibitory effect on the production of nitric oxide and prostaglandin E2, and showed a better inhibitory effect than hydrocortisone in inhibiting the production of pro-inflammatory cytokines, TNF-α and IL-6. In addition, mRNA expression of collagen type I alpha 1 was decreased by hydrocortisone in human dermal fibroblasts, which is associated with skin atrophy, however expression of COL1A1 was not affected by BSASM. Based on these results, it is expected that BSASM can be applied as a natural alternative to hydrocortisone in treatment of chronic inflammatory skin diseases.

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